Novel potentially biocompatible nanoporous hydrogel based on poly ((2-dimethylaminoethyl) methacrylate) grafted onto salep: synthesis, swelling behavior and drug release study

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• 作者：Ghasem Rezanejade Bardajee (1)
  Zari Hooshyar (1)
  
• 关键词：Hydrogel ; Salep ; Swelling ; Drug release
• 刊名：Journal of Polymer Research
• 出版年：2013
• 出版时间：January 2013
• 年：2013
• 卷：20
• 期：1
• 全文大小：1,993 KB
• 参考文献：1. Bardajee GR, Pourjavadi A, Soleyman R (2011) J Polym Res 18:337 CrossRef
  2. Pourjavadi A, Soleyman R, Bardajee GR (2010) Iran J Chem Chem Eng 29:113
  3. Pourjavadi A, Afjeh SS, Seidi F (2011) Appl Polym Sci 122:2424 CrossRef
  4. Pourjavadi A, Bardajee GR, Soleyman R (2009) Bull Korean Chem Soc 30:2680 CrossRef
  5. Khalil S, Sun W (2007) Mater Sci Eng C 27:469 CrossRef
  6. Chen J, Liu M, Liu H, Ma L (2009) Mater Sci Eng C 29:2116 CrossRef
  7. Pourjavadi A, Zeidabadi F, Barzegar S (2010) J Appl Polym Sci 118:2015
  8. Pourjavadi A, Jahromi PE, Seidi F, Salimi H (2010) Carbohydr Polym 79:933 CrossRef
  9. Pourjavadi A, Ghasemzadeh H, Soleyman R, Salimi H (2010) Iran Polym J 19:571
  10. Wu W, Liu J, Cao S, Tan H, Li J, Xu F, Zhang X (2011) Int J Pharm 416:104 CrossRef
  11. Chen X, Wu W, Guo Z, Xin J, Li J (2011) Biomaterials 32:1759 CrossRef
  12. Luo J, Cao S, Chen X, Li S, Tan H, Wu W, Li J (2012) Biomaterials 33:8733 CrossRef
  13. Zhang Z, Li J, Jiang W, Ren C, Li J, Xin J, Li K (2010) Int J Pharm 393:212 CrossRef
  14. Orakdogen N (2012) J Polym Res 19:9914 CrossRef
  15. Uzun C, Hassnisaber M, Sen M, Guven O (2003) Nucl Inst Methods Phys Res Sect B 208:242 CrossRef
  16. Sen M, Sar? M (2005) Eur Polym J 41:1304 CrossRef
  17. Nguyen MK, Huynh CT, Lee DS (2009) Polymer 50:5205 CrossRef
  18. George M, Abraham TE (2007) Int J Pharm 335:123 CrossRef
  19. Baumann MD, Kang CE, Tator CH, Shoichet MS (2010) Biomaterials 31:7631 CrossRef
  20. Rossi F, Santoro M, Casalini T, Perale G (2011) J Rare Earth 29:259 CrossRef
  21. Bardajee GR, Pourjavadi A, Soleyman R (2011) Ad Pol Tech 17:265
  22. Bardajee GR, Pourjavadi A, Soleyman R (2011) Colloids Surf A 392:16 CrossRef
  23. Pourjavadi A, Bardajee GR, Soleyman R (2009) J Appl Polym Sci 112:2625 CrossRef
  24. Bardajee GR, Pourjavadi A, Soleyman R, Sheikh N (2010) J Iran Chem Soc 7:652 CrossRef
  25. Pourjavadi A, Bardajee GR, Soleyman R (2008) Starch-Starke 60:467 CrossRef
  26. Bardajee GR, Pourjavadi A, Ghavami S, Soleyman R, Jafarpour F (2011) J Photochem Photobiol B 102:232 CrossRef
  27. Ktistis G, Georgakopoulos PP (1991) Pharmazie 46:55
  28. Farhoosh R, Riazi A (2007) Food Hydrocolloids 21:660 CrossRef
  29. Vuksan V, Jenkins DJ, Spadafora P, Sievenpiper JL, Owen R, Vidgen E (1999) Diabetes Care 22:913 CrossRef
  30. Reffo GC, Ghirardi PE, Forattani C (1990) Curr Ther Res 47:753
  31. Walsh DE, Yaghoubian V, Behforooz A (1984) Int J Obes 8:289
  32. Tekinsen KK, Guner A (2010) Food Chem 121:468 CrossRef
  33. Witono JR, Noordergraaf IW, Heeres HJ, Janssen LPBM (2012) Carbohydr Polym 90:1522 CrossRef
  34. Aminabhavi TM, Naik HG (1998) J Hazard Mater 60:175 CrossRef
  
• 作者单位：Ghasem Rezanejade Bardajee (1)
  Zari Hooshyar (1)
  
  1. Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran
  
• ISSN：1572-8935

文摘

A novel potentially biocompatible nanoporous hydrogel was synthesized via crosslinking graft copolymerization of (2-dimethylaminoethyl) methacrylate (DMA) monomer onto salep backbones. Methylenebisacrylamide (MBA) and ammonium persulfate (APS) were applied as water-soluble crosslinker and initiator, respectively. To investigate the structure of the obtained hydrogel, fourier transforms infrared spectroscopy (FT-IR), thermo-gravimetric analysis (TGA) and scanning electron microscopy (SEM) were used. Swelling behavior of the obtained hydrogel at different temperatures and pH media was investigated and it was found that the synthesized hydrogel has a high sensitivity to pH. The swelling first increased and then decreased with increasing pH from 2 to 12 at 37?°C and the maximum water absorbency was observed at pH--. Swelling reversibility of the hydrogel at pH 2.0 and 8.0 was examined to show the pH sensitivity and smartness of hydrogel. Lastly, the potential use of this hydrogel for the loading and releasing of tetracycline hydrochloride (TH) as a model drug was examined. The results showed that 95?% of TH was released at pH 8 after 4?h at 37?°C which were best fitted with Korsmeyer kinetic model.