Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women’s Health Study

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• 作者：Jonathan N Hofmann (10)
  Linda M Liao (10)
  Paul T Strickland (11)
  Xiao-Ou Shu (12)
  Gong Yang (12)
  Bu-Tian Ji (10)
  Hong-Lan Li (13)
  Nathaniel Rothman (10)
  Farin Kamangar (14)
  Yu-Tang Gao (13)
  Wei Zheng (12)
  Wong-Ho Chow (15)
  
• 关键词：1 ; hydroxypyrene glucuronide ; Polycyclic aromatic hydrocarbons ; Colorectal cancer ; China
• 刊名：BMC Cancer
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：13
• 期：1
• 全文大小：198KB
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  31. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/13/282/prepub
  
• 作者单位：Jonathan N Hofmann (10)
  Linda M Liao (10)
  Paul T Strickland (11)
  Xiao-Ou Shu (12)
  Gong Yang (12)
  Bu-Tian Ji (10)
  Hong-Lan Li (13)
  Nathaniel Rothman (10)
  Farin Kamangar (14)
  Yu-Tang Gao (13)
  Wei Zheng (12)
  Wong-Ho Chow (15)
  
  10. Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Room 6E132, MSC 9771, Bethesda, MD, 20892, USA
  11. Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
  12. Department of Medicine, Vanderbilt University, School of Medicine, Nashville, TN, USA
  13. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
  14. Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, MD, USA
  15. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
  
• ISSN：1471-2407

文摘

Background Associations between polycyclic aromatic hydrocarbons (PAHs) and colorectal cancer have been reported previously but few studies have characterized PAH exposure using biological measurements. We evaluated colorectal cancer risk in relation to urinary concentration of 1-hydroxypyrene glucuronide (1-OHPG), a polycyclic aromatic hydrocarbon (PAH) metabolite, and assessed determinants of PAH exposure among controls in the Shanghai Women’s Health Study (SWHS). Methods Concentrations of 1-OHPG were measured in spot urine samples collected from 343 colorectal cancer cases and 343 individually matched controls. Questionnaires were administered to collect information on demographic characteristics and reported exposures. Odds ratios were calculated for risk of colorectal cancer in relation to quartiles of urinary 1-OHPG concentration. Potential determinants of natural log-transformed urinary 1-OHPG concentration were evaluated among a combined sample of controls from this study and another nested case–control study in the SWHS (Ntotal=652). Results No statistically significant differences in risk of colorectal cancer by urinary 1-OHPG levels were observed. Among controls, the median (interquartile range) urinary 1-OHPG concentration was 2.01 pmol/mL (0.95-4.09). Active and passive smoking, using coal as a cooking fuel, eating foods that were cooked well done, and recent consumption of fried dough (e.g., yóutiáo) were associated with elevated levels of 1-OHPG, though only active smoking and fried dough consumption achieved statistical significance in multivariate analyses. Conclusions This study does not provide evidence of an association between urinary levels of 1-OHPG and risk of colorectal cancer among women. Several environmental and dietary sources of PAH exposure were identified. Overall, the levels of 1-OHPG in this population of predominantly non-smoking women were considerably higher than levels typically observed among non-smokers in Europe, North America, and other developed regions.