Endoglin (CD105) expression in sinonasal polyposis

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• 作者：Giancarlo Ottaviano ; Rocco Cappellesso…
• 关键词：Nasal polyposis ; Surgery ; Nasal polyps relapse ; CD105
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：272
• 期：11
• 页码：3367-3373
• 全文大小：872 KB
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• 作者单位：Giancarlo Ottaviano (1)
  Rocco Cappellesso (2)
  Ioannis Mylonakis (1)
  Marco Lionello (1)
  Niccolò Favaretto (1)
  Luciano Giacomelli (2)
  Cristiano Spoladore (2)
  Rosario Marchese-Ragona (1)
  Filippo Marino (2)
  Alberto Staffieri (1)
  Alessandro Martini (1)
  Gino Marioni (1)
  
  1. Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy
  2. Department of Medicine DIMED, Padova University, Padua, Italy
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Otorhinolaryngology
  Neurosurgery
  Head and Neck Surgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1434-4726

文摘

Despite appropriate surgical therapy, 5-0 % of patients with chronic rhinosinusitis (CRS) and nasal polyps (NP) experience disease recurrences. It has been suggested that angiogenesis may relate to the pathogenesis and prognosis of CRS with NP. Endoglin (CD105) is a component of the receptor complex of transforming growth factor-beta, a pleiotropic cytokine that modulates angiogenesis. A series of patients treated surgically for CRS with NP was analyzed to assess the relationship between CD105 expression, main clinicopathological features, and recurrence rate. The immunohistochemical expression of CD105 was assessed in 70 patients consecutively operated for CRS with NP. In the univariate setting, the presence of CD105 (1/0) showed a trend towards a significant association with increasing NP dimensions (p = 0.054). Intensity of CD105 reaction was also significantly associated with NP size (0.04) and with an eosinophilic histology (p = 0.048). In our multivariate setting, only asthma (p = 0.016), hypereosinophilia (p = 0.022), and preoperative polyposis score (p = 0.046) retained their independent prognostic significance in relation to NP recurrence. Further efforts are needed to elucidate the biological, angiogenic and proliferative mechanisms behind recurrent NP. Our preliminary results support the clinical utility of extra postoperative care, in terms of closer follow-ups and medication with oral anti-histamines, topical and/or oral steroids, and antileukotrienes in patients with asthma, advanced nasal polyposis at presentation, and serum hypereosinophilia. Keywords Nasal polyposis Surgery Nasal polyps relapse CD105