Maintenance of whole-body therapeutic hypothermia during patient transport and magnetic resonance imaging

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• 作者：Tai-Wei Wu (1) (2) (4)
  Claire McLean (1) (2)
  Philippe Friedlich (1) (2)
  John Grimm (2) (3)
  Stefan Bluml (2) (3)
  Istvan Seri (1) (2)
  
• 关键词：Neonatal hypoxic–ischemic encephalopathy ; Brain temperature ; Therapeutic hypothermia ; In ; house transport ; Magnetic resonance imaging ; Neonate
• 刊名：Pediatric Radiology
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：44
• 期：5
• 页码：613-617
• 全文大小：703 KB
• 参考文献：1. De Vries LS, Jongmans MJ (2010) Long-term outcome after neonatal hypoxic–ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 95:F220–F224 CrossRef
  2. Shankaran S, Pappas A, McDonald SA et al (2012) Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 366:2085-092 CrossRef
  3. Neil J (2010) Is MRI still cool after hypothermia? Lancet Neurol 9:19-0 CrossRef
  4. Wintermark P, Hansen A, Soul J et al (2011) Early versus late MRI in asphyxiated newborns treated with hypothermia. Arch Dis Child Fetal Neonatal Ed 96:F36–F44 CrossRef
  5. Wintermark P, Labrecque M, Warfield SK et al (2010) Can induced hypothermia be assured during brain MRI in neonates with hypoxic–ischemic encephalopathy? Pediatr Radiol 40:1950-954 CrossRef
  6. Rutherford M, Srinivasan L, Dyet L et al (2006) Magnetic resonance imaging in perinatal brain injury: clinical presentation, lesions and outcome. Pediatr Radiol 36:582-92 CrossRef
  7. Corbett RJ, Laptook AR, Tollefsbol G et al (1995) Validation of a noninvasive method to measure brain temperature in vivo using 1H NMR spectroscopy. J Neurochem 64:1224-230 CrossRef
  
• 作者单位：Tai-Wei Wu (1) (2) (4)
  Claire McLean (1) (2)
  Philippe Friedlich (1) (2)
  John Grimm (2) (3)
  Stefan Bluml (2) (3)
  Istvan Seri (1) (2)
  
  1. Center for Fetal and Neonatal Medicine and the USC Division of Neonatal Medicine, Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA, USA
  2. LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
  4. Division of Neonatal Medicine, Children’s Hospital Los Angeles, 4650 Sunset Blvd., Los Angeles, CA, 90027, USA
  3. Department of Radiology, Children’s Hospital Los Angeles, Los Angeles, CA, USA
  
• ISSN：1432-1998

文摘

Therapeutic hypothermia has become standard treatment for neonatal hypoxic–ischemic encephalopathy (HIE), with brain MRI commonly performed after the child has been rewarmed. However, early imaging during hypothermia might provide information important in designing clinical trials that refine and personalize therapeutic hypothermia. We tested a protocol to ensure safety and maintenance of hypothermia during in-hospital transport and MRI. MRI during therapeutic hypothermia was performed in 13 newborns on the 2nd-3rd postnatal days. Mean one-way transport time was 20.0?±-.3?min. Mean rectal temperatures (°C) leaving the unit, upon arrival at the MR suite, during MRI scan and upon return to the unit were 33.5?±-.3°C, 33.3?±-.3°C, 33.1?±-.4°C and 33.4?±-.3°C, respectively. Using our protocol therapeutic hypothermia was safely and effectively continued during in-hospital transport and MRI without adverse effects.