Partially purified components of Uncaria sinensis attenuate blood brain barrier disruption after ischemic brain injury in mice

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• 作者：Hyung Bum Seo ; Bo Kyung Kang ; Ji Hyun Kim…
• 关键词：Blood–brain barrier ; Focal cerebral ischemia ; MMP ; Tight junction protein ; Uncaria sinensis
• 刊名：BMC Complementary and Alternative Medicine
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：1,801 KB
• 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
• 出版者：BioMed Central
• ISSN：1472-6882

文摘

Background Uncaria sinensis (US) has long been used in traditional Korean medicine to relieve various nervous-related symptoms and cardiovascular disease. We recently showed the neuroprotective and cerebrovascular protective effects of US on cerebral ischemia; however, its effects on the blood–brain barrier (BBB) are poorly understood. In this study, the effects of partially purified components of US (PPUS) on BBB disruption were investigated in mice subjected to ischemic brain injury.