Effects of Different Concentrations of Injectable Collagenase Enzyme on Capsular Tissue Around Silicone Implants: A Preliminary Experimental Study for the Development of a New Treatment Strategy

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• 作者：Nebil Yeşiloğlu ; Gökhan Temiz ; Murat Sarıcı ; Kemalettin Yıldız…
• 关键词：Clostridium histolyticum collagenase ; Capsular contracture ; Silicone implants ; Breast implants
• 刊名：Aesthetic Plastic Surgery
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：40
• 期：1
• 页码：164-173
• 全文大小：2,151 KB
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• 作者单位：Nebil Yeşiloğlu (1)
  Gökhan Temiz (1)
  Murat Sarıcı (1)
  Kemalettin Yıldız (2)
  Hakan Şirinoğlu (1)
  Emre Güvercin (1)
  Ali Cem Akpınar (1)
  Gaye Taylan Filinte (1)
  Deniz Filinte (3)
  
  1. Department of Plastic Reconstructive and Aesthetic Surgery, Dr. Lütfi Kırdar Kartal Training and Research Hospital, Acıbadem Mh. Gömeç Sk. Sabancı-1 Sitesi 8/16 Kadıköy, Kartal, Istanbul, 34718, Turkey
  2. Department of Plastic Reconstructive and Aesthetic Surgery, Bezmialem Vakıf University Medical Faculty, Fatih, Istanbul, Turkey
  3. Department of Pathology, Marmara University, Istanbul, Turkey
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Plastic Surgery
  Otorhinolaryngology
  
• 出版者：Springer New York
• ISSN：1432-5241

文摘

Objectives In recent studies, collagen organization was blamed for the formation of capsular contracture which is still a challenging problem after silicone implant-based breast operations. In this study, effects of different concentrations of collagenase enzyme derived from Clostridium histolyticum on the capsular tissue formation around the silicone implants were investigated. The injectable form of collagenase has a routine clinical use in the treatment of both Dupuytren’s and Peyronie’s diseases.