Comparison of in vivo immune responses following transplantation of vascularized and non-vascularized human dermo-epidermal skin substitutes

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• 作者：Agnes S. Klar ; Thomas Biedermann ; Claudia Simmen-Meuli…
• 关键词：Bio ; engineered human skin graft ; Skin vascularization ; Inflammatory tissue response ; Macrophage recruitment ; Granulocyte infiltration
• 刊名：Pediatric Surgery International
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：33
• 期：3
• 页码：377-382
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Pediatrics; Surgery; Pediatric Surgery;
• 出版者：Springer Berlin Heidelberg
• ISSN：1437-9813
• 卷排序：33

文摘

PurposeAutologous bio-engineered dermo-epidermal skin substitutes (DESS) represent an alternative therapeutic option for a definitive treatment of skin defects in human patients. Largely, the interaction of host immune cells with transplanted DESS is considered to be essential for the granulation tissue formation, graft take, and its functionality. The aim of this study was to compare the spatiotemporal distribution and density of host-derived monocytes/macrophages and granulocytes in vascularized (vascDESS) versus non-vascularized DESS (non-vascDESS) in a rat model.