Hot executive control and response to a stimulant in a double-blind randomized trial in children with ADHD
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  • 作者:Jessica Yarmolovsky ; Tamar Szwarc…
  • 关键词:Methylphenidate ; ADHD ; Executive control ; Children
  • 刊名:European Archives of Psychiatry and Clinical Neuroscience
  • 出版年:2017
  • 出版时间:February 2017
  • 年:2017
  • 卷:267
  • 期:1
  • 页码:73-82
  • 全文大小:575KB
  • 刊物类别:Medicine
  • 刊物主题:Psychiatry; Neurosciences; Neurology;
  • 出版者:Springer Berlin Heidelberg
  • ISSN:1433-8491
  • 卷排序:267
文摘
Attention deficit hyperactivity disorder (ADHD) is thought to involve an executive inhibitory control (IC) deficit, yet it is not clear if this is a general deficit affecting both cold and hot EC, and if methylphenidate (MPH) affects both systems in treated children. We explored this by using a Stroop-like task in children with ADHD as compared to controls, containing different types of emotional stimuli (six levels), and we investigated the role of intervention with MPH on IC as compared to placebo. Children with ADHD and controls (N = 40; 7–13 years old) were tested with a hot and cold Stroop-like task. This was followed by a double-blind placebo-controlled crossover trial of the effect of MPH on these skills. Children with ADHD showed a specific difficulty inhibiting their responses, particularly to hot, angry and frustration-inducing stimuli. Further, treatment with MPH was effective in reducing errors toward frustration-inducing stimuli as compared to placebo (p < .05, η2 = .347), particularly with repeated exposure to the stimuli. Results indicate that children with ADHD experience executive control difficulties, particularly in hot negative emotional contexts. These emotion regulation difficulties are amenable to stimulant intervention.
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