Improving protein complex prediction by reconstructing a high-confidence protein-protein interaction network of Escherichia coli from different physical interaction data sources

详细信息    查看全文

• 作者：Shirin Taghipour ; Peyman Zarrineh ; Mohammad Ganjtabesh…
• 关键词：Protein ; protein interaction networks ; Protein complexes ; Biological networks ; Network clustering ; Functional networks
• 刊名：BMC Bioinformatics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：1031KB
• 刊物主题：Bioinformatics; Microarrays; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Algorithms;
• 出版者：BioMed Central
• ISSN：1471-2105
• 卷排序：18

文摘

BackgroundAlthough different protein-protein physical interaction (PPI) datasets exist for Escherichia coli, no common methodology exists to integrate these datasets and extract reliable modules reflecting the existing biological process and protein complexes. Naïve Bayesian formula is the highly accepted method to integrate different PPI datasets into a single weighted PPI network, but detecting proper weights in such network is still a major problem.