Neurosyphilis Update: Atypical is the New Typical

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• 作者：Salman Bhai ; Jennifer L. Lyons
• 关键词：Neurosyphilis ; Syphilis ; HIV ; Neuroinfectious diseases ; Dementia
• 刊名：Current Infectious Disease Reports
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：17
• 期：5
• 全文大小：590 KB
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• 作者单位：Salman Bhai (1)
  Jennifer L. Lyons (1) (2)
  
  1. Harvard Medical School, Boston, MA, USA
  2. Division of Neurological Infections, Brigham and Women’s Hospital, 45 Francis Street, Boston, MA, 02115, USA
  
• 刊物主题：Infectious Diseases;
• 出版者：Springer US
• ISSN：1534-3146

文摘

Syphilis has reemerged as an important cause of neurological disease, affecting any part of the neuraxis at any stage of infection. What was once a dwindling diagnosis is now redoubling, particularly in the HIV-positive and in men who have sex with men?populations. In the era of antibiotics and HIV coinfection, neurosyphilis presentations are protean, making diagnosis notoriously challenging. Advanced disease may be irreversible, and so early detection and treatment are ideal. Herein, we review recent advances in understanding neurosyphilis.