Synthesis and biological evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents

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• 作者：Shenghui Li (1)
  Shengjie Xu (1)
  Shan Ding (1)
  Jinchao Zhang (1)
  Shuxiang Wang (1)
  Xiaoliu Li (1)
  
• 关键词：Synthesis ; N ; arylpyrazole ; Cytotoxicity ; Cancer cell lines
• 刊名：Research on Chemical Intermediates
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：40
• 期：4
• 页码：1459-1468
• 全文大小：298 KB
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• 作者单位：Shenghui Li (1)
  Shengjie Xu (1)
  Shan Ding (1)
  Jinchao Zhang (1)
  Shuxiang Wang (1)
  Xiaoliu Li (1)
  
  1. Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, College of Chemistry & Environmental Science, Hebei University, Baoding, 071002, People’s Republic of China
  
• ISSN：1568-5675

文摘

A series of novel N-arylpyrazole derivatives, 5a-strong class="a-plus-plus">5i, were achieved from substituted phenylacetic acid via Vilsmeier–Haack reaction, hydrolysis, condensation, and aromatic substitution reaction. Their chemical structures were confirmed by 1H NMR, 13C NMR, FTIR, HRMS, and elemental analysis. The newly synthesized compounds were tested for their in vitro cytotoxic activity against Bel-7402, KB, HL-60, and BGC-823 cell lines and found to possess moderate activity.