Mitochondrial proteomes of porcine kidney cortex and medulla: foundation for translational proteomics

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• 作者：Zdenek Tuma ; Jitka Kuncova ; Jan Mares…
• 关键词：Mitochondria ; Pig kidney ; Proteomics ; Two ; dimensional electrophoresis
• 刊名：Clinical and Experimental Nephrology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：20
• 期：1
• 页码：39-49
• 全文大小：1,830 KB
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• 作者单位：Zdenek Tuma (1)
  Jitka Kuncova (1) (2)
  Jan Mares (1) (3)
  Martin Matejovic (1) (3)
  
  1. Faculty of Medicine in Plzen, Biomedical Center, Charles University in Prague, alej Svobody, 1655/76, Plzen, Czech Republic
  2. Department of Physiology, Charles University Medical School, Plzen, Czech Republic
  3. Department of Internal Medicine I, Charles University Medical School and Teaching Hospital, Plzen, Czech Republic
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Nephrology
  Internal Medicine
  Urology and Andrology
  
• 出版者：Springer Japan
• ISSN：1437-7799

文摘

Background Emerging evidence has linked mitochondrial dysfunction to the pathogenesis of many renal disorders, including acute kidney injury, sepsis and even chronic kidney disease. Proteomics is a powerful tool in elucidating the role of mitochondria in renal pathologies. Since the pig is increasingly recognized as a major mammalian model for translational research, the lack of physiological proteome data of large mammals prompted us to examine renal mitochondrial proteome in porcine kidney cortex and medulla