Plasma Kynurenic Acid Concentration in Patients Undergoing Cardiac Surgery: Effect of Anaesthesia

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• 作者：Edyta Kotlinska-Hasiec (1)
  Patrycja Nowicka-Stazka (2)
  Jolanta Parada-Turska (3)
  Krzysztof Stazka (4)
  Janusz Stazka (5)
  Przemyslaw Zadora (1)
  Wojciech Dabrowski (1)
  
  1. Department of Anaesthesiology and Intensive Therapy ; Medical University of Lublin ; Jaczewskiego 8 ; 20-954 ; Lublin ; Poland
  2. Department of Endocrinology ; Medical University of Lublin ; Lublin ; Poland
  3. Department of Rheumatology and Connective Tissue Diseases ; Medical University of Lublin ; Lublin ; Poland
  4. Department of Cardiology ; Medical University of Lublin ; Lublin ; Poland
  5. Department of Cardiac Surgery ; Medical University of Lublin ; Lublin ; Poland
  
• 关键词：Kynurenic acid ; Neutrophil/lymphocyte ratio ; Sevoflurane ; Cardiac surgery ; General anaesthesia
• 刊名：Archivum Immunologiae et Therapiae Experimentalis
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：63
• 期：2
• 页码：129-137
• 全文大小：558 KB
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• 刊物主题：Immunology; Pharmacology/Toxicology;
• 出版者：Springer Basel
• ISSN：1661-4917

文摘

Increases in plasma kynurenic acid (KYNA) concentration relate to the severity of inflammation. The aim of this study was to analyse changes in plasma KYNA concentration and neutrophil/lymphocyte ratio (NLR) in cardiac surgery patients. Additionally, the effect of anaesthesia was analysed. Adult cardiac surgery patients under intravenous general anaesthesia were studied. Additionally, some patients received sevoflurane (SEV) prior to cardiopulmonary bypass. Plasma KYNA concentration and NLR were measured before anaesthesia, just after surgery and on postoperative days 1, 2 and 3. Patients were assigned to two groups: patients who did not receive SEV (NonSEV group) and patients who received SEV (SEV group). Forty-three patients were studied. Twenty-four of them received SEV. KYNA increased immediately after surgery and remained elevated through postoperative day 3 in the NonSEV group, whereas it was similar to the preoperative concentration in the SEV group. NLR increased immediately after surgery in both groups, and higher values were noted in the NonSEV group than in the SEV group at postoperative days 2 and 3. Plasma KYNA concentration correlated with NLR in the NonSEV group. Cardiac surgery caused an increase in NLR. Plasma KYNA increased in the NonSEV group and correlated with NLR. Administration of SEV inhibited the increase in KYNA, most likely due to its anti-inflammatory properties.