Oral Microflora: A Comparative Study in HIV and Normal Patients

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• 作者：Mahesh Chandra Hegde (1)
  Abhijit Kumar (2)
  Gopalkrishna Bhat (1)
  Suja Sreedharan (1)
  
• 关键词：HIV ; Normal ; Oral microflora ; Micrococcus
• 刊名：Indian Journal of Otolaryngology and Head & Neck Surgery
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：66
• 期：1-supp
• 页码：126-132
• 全文大小：186 KB
• 作者单位：Mahesh Chandra Hegde (1)
  Abhijit Kumar (2)
  Gopalkrishna Bhat (1)
  Suja Sreedharan (1)
  
  1. Department of Otolaryngology, Kasturba Medical College Hospital, Attavara, Mangalore, 575001, India
  2. Vinayaka Missions Kripananda Variyar Medical College, Salem, Tamil Nadu, India
  
• ISSN：0973-7707

文摘

The study was designed to compare the oral microbiota in normal and HIV-infected individuals. The study tries to establish a significant shift in oral microflora in HIV-infected patients. Antibiotic sensitivity testing was performed to establish any rise in resistance against the antibiotics. It was a two and half year prospective study conducted in a tertiary care centre. The study group consisted of eighty subjects divided into two groups of control and HIV. The age range for this group was 9-5?years. The mean age in this group was 39.7?years. The male:female ratio was 2.75:1. Tuberculosis was the most common opportunistic infection in patients with HIV infection. The most common commensal micro organism isolated was the Viridans streptococci in 60% followed by Streptococcus pneumoniae in 23.33%. HIV Group: The most common commensal micro organism isolated was the Viridans streptococci in 42%; this was followed by the Micrococci spp. in 22% cases. S. pneumoniae was isolated in 6% of cases. The colony count for Viridans streptococci showed a heavy growth in 55.56% of cases in controls whereas the same in HIV group was 62.5%. Micrococcus spp. was isolated from 11 subjects in HIV group while it was not isolated from the controls. 50% subjects in the HIV group showed a heavy growth of Klebsiella spp. whereas controls showed only moderate and scanty growth. In patients with CD4+ T cell count less than 50?cells/μl we found a heavy colonization of the oral cavity with Micrococcus spp., Acinetobacter and Klebsiella spp. Viridans streptococcus was not isolated in any of the patients with CD4+ T cell count less than 50?cells/μl. As CD4+ T cells counts improved to 51-00?cells/μl Viridans streptococcus colonies returned and 37.5% patients showed a heavy growth. Micrococcus spp. colonies were isolated till the CD4+ T cells improved up to 300?cells/μl. At counts?>?300?cells/μl the oral microbiota became comparable to that of the controls. Many of the opportunistic infections in HIV are caused by commensal bacteria which are otherwise harmless in a normal individual. Our study is unique in that such a study of the oral commensals in HIV patients has never been reported. We found an increased colonization of the oral cavity by Micrococcus spp. which is a normal commensal of the skin.