Infiltration of diametrically polarized macrophages predicts overall survival of patients with gastric cancer after surgical resection

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• 作者：Heng Zhang ; Xuefei Wang ; Zhenbin Shen ; Jiejie Xu ; Jing Qin ; Yihong Sun
• 关键词：Gastric cancer ; Tumor ; associated macrophages ; Prognosis ; Nomogram ; Overall survival
• 刊名：Gastric Cancer
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：18
• 期：4
• 页码：740-750
• 全文大小：2,297 KB
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• 作者单位：Heng Zhang (1)
  Xuefei Wang (1)
  Zhenbin Shen (1)
  Jiejie Xu (2) (3)
  Jing Qin (1)
  Yihong Sun (1)
  
  1. Department of General Surgery, Zhongshan Hospital, Shanghai Medical College of Fudan University, 180 Feng Lin Road, Shanghai, 200032, China
  2. Key Laboratory of Glycoconjugate Research, Ministry of Health, Shanghai, China
  3. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, 138 Yi Xue Yuan Road, PO Box 103, Shanghai, 200032, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Gastroenterology
  Surgical Oncology
  Pathology
  Radiotherapy
  
• 出版者：Springer Japan
• ISSN：1436-3305

文摘

Background Tumor-associated macrophages (TAMs), the most predominant tumor-infiltrating immune cells, are emerging prognostic factors and therapeutic targets for personalized therapy against malignant neoplasms. We aimed to evaluate the prognostic significance of diametrically polarized TAMs in gastric cancer and generate a predictive nomogram to refine a risk stratification system.