ProtDCal: A program to compute general-purpose-numerical descriptors for sequences and 3D-structures of proteins

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• 作者：Yasser B Ruiz-Blanco ; Waldo Paz ; James Green ; Yovani Marrero-Ponce
• 关键词：ProtDCal ; Protein feature generation ; Protein descriptors ; Data mining ; Protein function modelling
• 刊名：BMC Bioinformatics
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：16
• 期：1
• 全文大小：2,203 KB
• 刊物主题：Bioinformatics; Microarrays; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Combinatorial Libraries; Algorithms;
• 出版者：BioMed Central
• ISSN：1471-2105

文摘

Background The exponential growth of protein structural and sequence databases is enabling multifaceted approaches to understanding the long sought sequence-structure-function relationship. Advances in computation now make it possible to apply well-established data mining and pattern recognition techniques to these data to learn models that effectively relate structure and function. However, extracting meaningful numerical descriptors of protein sequence and structure is a key issue that requires an efficient and widely available solution.