Meiotic outcome in two carriers of Y autosome reciprocal translocations: selective elimination of certain segregants

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• 作者：Harita Ghevaria ; Roy Naja ; Sioban SenGupta ; Paul Serhal…
• 关键词：Y ; autosome Translocation ; Meiosis ; Segregation ; Infertility
• 刊名：Molecular Cytogenetics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：797KB
• 刊物主题：Cytogenetics; Molecular Medicine; Human Genetics;
• 出版者：BioMed Central
• ISSN：1755-8166
• 卷排序：10

文摘

BackgroundReciprocal Y autosome translocations are rare but frequently associated with male infertility. We report on the meiotic outcome in embryos fathered by two males with the karyotypes 46,X,t(Y;4)(q12;p15.32) and 46,X,t(Y;16)(q12;q13). The two couples underwent preimplantation genetic diagnosis (PGD) enabling determination of the segregation types that were compatible with fertilization and preimplantation embryo development. Both PGD and follow up analysis were carried out via fluorescence in situ hybridization (FISH) or array comparative genomic hybridization (aCGH) allowing the meiotic segregation types to be determined in a total of 27 embryos.