Microparticles shed from multidrug resistant breast cancer cells provide a parallel survival pathway through immune evasion

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• 作者：Ritu Jaiswal ; Michael S. Johnson ; Deep Pokharel ; S. Rajeev Krishnan…
• 关键词：Cancer ; Extracellular vesicles ; Immune evasion ; Macrophage ; Microparticles ; Multidrug resistance ; Cell engulfment
• 刊名：BMC Cancer
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：2426KB
• 刊物主题：Cancer Research; Oncology; Surgical Oncology; Health Promotion and Disease Prevention; Biomedicine, general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1471-2407
• 卷排序：17

文摘

BackgroundBreast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune response against foreign infiltrates. Despite extensive characterization of the role of macrophages and other immune cells in malignant tissues, there is very little known about the mechanisms which facilitate metastatic breast cancer spread to distant sites of immunological integrity. The mechanisms by which a key healthy defense mechanism fails to protect distant sites from infiltration by metastatic cells in cancer patients remain undefined.