Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy

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• 作者：Wei Xie (16) (17) (18)
  Lun Cai (17) (18) (19)
  Yunhong Yu (20)
  Liang Gao (18)
  Limin Xiao (18)
  Qianchao He (19)
  Zhijun Ren (17)
  Yuanzheng Liu (17)
  
• 关键词：1 ; methyltryptophan ; Minocycline ; Kynurenine ; Tryptophan ; Serotonin ; Interleukin ; 1β ; Interleukin ; 6 ; Taste preference test ; Forced swim test ; Epilepsy ; Depression
• 刊名：Journal of Neuroinflammation
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：11
• 期：1
• 全文大小：377 KB
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• 作者单位：Wei Xie (16) (17) (18)
  Lun Cai (17) (18) (19)
  Yunhong Yu (20)
  Liang Gao (18)
  Limin Xiao (18)
  Qianchao He (19)
  Zhijun Ren (17)
  Yuanzheng Liu (17)
  
  16. Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
  17. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, People’s Republic of China
  18. Southern Medical University, Guangzhou, People’s Republic of China
  19. Department of Encephalopathy, The first affiliated hosipital of Guangxi University of Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, People’s Republic of China
  20. Department of Traditional Chinese Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guang Zhou, 510080, China
  
• ISSN：1742-2094

文摘

Background Depression has most often been diagnosed in patients with temporal lobe epilepsy (TLE), but the mechanism underlying this association remains unclear. In this study, we report that indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in epilepsy-associated depressive-like behavior. Methods Rats which develop chronic epilepsy following pilocarpine status epilepticus exhibited a set of interictal disorders consistent with depressive-like behavior. Changes of depressive behavior were examined by taste preference test and forced swim test; brain IL-1β, IL-6 and IDO1 expression were quantified using real-time reverse transcriptase PCR; brain kynurenine/tryptophan and serotonin/tryptophan ratios were analyzed by liquid chromatography-mass spectrometry. Oral gavage of minocycline or subcutaneous injection of 1-methyltryptophan (1-MT) were used to inhibite IDO1 expression. Results We observed the induction of IL-1β and IL-6 expression in rats with chronic TLE, which further induced the upregulation of IDO1 expression in the hippocampus. The upregulation of IDO1 subsequently increased the kynurenine/tryptophan ratio and decreased the serotonin/tryptophan ratio in the hippocampus, which contributed to epilepsy-associated depressive-like behavior. The blockade of IDO1 activation prevented the development of depressive-like behavior but failed to influence spontaneous seizures. This effect was achieved either indirectly, through the anti-inflammatory tetracycline derivative minocycline, or directly, through the IDO antagonist 1-MT, which normalizes kynurenine/tryptophan and serotonin/tryptophan ratios. Conclusion Brain IDO1 activity plays a key role in epileptic rats with epilepsy-associated depressive-like behavior.