Simple and facile electrocatalytic approach to medicinally relevant spirocyclopropylpyrazolones directly from pyrazoline-5-ones and activated olefins

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• 作者：Michail N. Elinson ; Evgeniya O. Dorofeeva…
• 关键词：Electrocatalysis ; Cascade reaction ; Undivided cell ; Pyrazoline ; 5 ; ones ; Activated olefins ; Spirocyclopropylpyrazolones
• 刊名：Research on Chemical Intermediates
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：42
• 期：3
• 页码：2191-2200
• 全文大小：472 KB
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• 作者单位：Michail N. Elinson (1)
  Evgeniya O. Dorofeeva (1)
  Anatoly N. Vereshchagin (1)
  Alexander D. Korshunov (1)
  Mikhail P. Egorov (1)
  
  1. N. D. Zelinsky Institute of Organic Chemistry, Leninsky Prospect 47, 119991, Moscow, Russia
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1568-5675

文摘

The electrolysis of pyrazoline-5-ones and activated olefins in the presence of sodium bromide as mediator in alcohols in an undivided cell results in efficient formation of the substituted spirocyclopropylpyrazolones in 50–85 % yields. This novel electrocatalytic process opens a convenient way to functionalized spirocyclopropylpyrazolones—the promising compounds for the different biomedical applications. Thus, the simple electrocatalytic system can produce in an undivided cell under mild conditions the electrochemically induced cascade reaction of pyrazoline-5-ones with activated olefins.