Measurements of C-reactive protein (CRP) and nerve-growth-factor (NGF) concentrations in serum and urine samples of dogs with neurologic disorders
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  • 作者:Ulrike Kordass ; Regina Carlson ; Veronika Maria Stein…
  • 关键词:Dog ; Nerve growth factor ; C ; reactive protein ; Micturition disorders ; Spinal cord disease ; Cystitis
  • 刊名:BMC Veterinary Research
  • 出版年:2016
  • 出版时间:December 2016
  • 年:2016
  • 卷:12
  • 期:1
  • 全文大小:716 KB
  • 参考文献:1.Granger N, Chew D, Fairhurst P, Fawcett JW, Lacour SP, Craggs M, et al. Use of an implanted sacral nerve stimulator to restore urine voiding in chronically paraplegic dogs. J vetintern med/American college of veterinary internal medicine. 2013;27(1):99–105.CrossRef
    2.Ross JC. Management of the bladder in spinal injuries. Br Med J. 1951;1(4707):616–9.PubMed PubMedCentral CrossRef
    3.Fluehmann G, Doherr MG, Jaggy A. Canine neurological diseases in a referral hospital population between 1989 and 2000 in Switzerland. J Small Anim Pract. 2006;47(10):582–7.PubMed CrossRef
    4.de Groat WC, Yoshimura N. Plasticity in reflex pathways to the lower urinary tract following spinal cord injury. Exp Neurol. 2012;235(1):123–32.PubMed PubMedCentral CrossRef
    5.Yoshimura N, Ogawa T, Miyazato M, Kitta T, Furuta A, Chancellor MB, et al. Neural mechanisms underlying lower urinary tract dysfunction. Korean journal of urology. 2014;55(2):81–90.PubMed PubMedCentral CrossRef
    6.Arnold S, Steffen F, Jaggy A. Blasenstörungen. In: Atlas und Lehrbuch der Kleintierneurologie. 2nd ed. Hannover: Schlütersche Verlagsgesellschaft mbH & Co; 2007. p. 333–68.
    7.Smee N, Loyd K, Grauer G. UTIs in small animal patients: part 1: etiology and pathogenesis. J Am Anim Hosp Assoc. 2013;49(1):1–7.PubMed CrossRef
    8.Norris CR, Williams BJ, Ling GV, Franti Johnson CE, Ruby AL. Recurrent and persistent urinary tract infections in dogs: 383 cases (1969–1995). J Am Anim Hosp Assoc. 2000;36(6):484–92.PubMed CrossRef
    9.Wooley RE, Blue JL. Quantitative and bacteriological studies of urine specimens from canine and feline urinary tract infections. J Clin Microbiol. 1976;4(4):326–9.PubMed PubMedCentral
    10.Smee N, Loyd K, Grauer GF. UTIs in small animal patients: part 2: diagnosis, treatment, and complications. J Am Anim Hosp Assoc. 2013;49(2):83–94.PubMed CrossRef
    11.Stiffler KS, Stevenson MA, Sanchez S, Barsanti JA, Hofmeister E, Budsberg SC. Prevalence and characterization of urinary tract infections in dogs with surgically treated type 1 thoracolumbar intervertebral disc extrusion. Vet Surg. 2006;35(4):330–6.PubMed CrossRef
    12.Bubenik L, Hosgood G. Urinary tract infection in dogs with thoracolumbar intervertebral disc herniation and urinary bladder dysfunction managed by manual expression, indwelling catheterization or intermittent catheterization. Vet Surg. 2008;37(8):791–800.PubMed CrossRef
    13.Olby NJ, MacKillop E, Cerda-Gonzalez S, Moore S, Munana KR, Grafinger M, et al. Prevalence of urinary tract infection in dogs after surgery for thoracolumbar intervertebral disc extrusion. J vet intern med / American college of veterinary internal medicine. 2010;24(5):1106–11.CrossRef
    14.Fry CH, Sahai A, Vahabi B, Kanai AJ, Birder LA. What is the role for biomarkers for lower urinary tract disorders? Neurourol urodyn. 2014;33(5):602–5.PubMed CrossRef
    15.Schoeman JP, Goddard A, Leisewitz AL. Biomarkers in canine parvovirus enteritis. N Z Vet J. 2013;61(4):217–22.PubMed CrossRef
    16.Bhide AA, Cartwright R, Khullar V, Digesu GA. Biomarkers in overactive bladder. Internat urogynecol j. 2013;24(7):1065–72.CrossRef
    17.Levi-Montalcini R, Skaper SD, Dal Toso R, Petrelli L, Leon A. Nerve growth factor: from neurotrophin to neurokine. Trends Neurosci. 1996;19(11):514–20.PubMed CrossRef
    18.Pezet S, McMahon SB. Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci. 2006;29:507–38.PubMed CrossRef
    19.Ochodnicky P, Cruz CD, Yoshimura N, Michel MC. Nerve growth factor in bladder dysfunction: contributing factor, biomarker, and therapeutic target. NeurourolUrodyn. 2011;30(7):1227–41.
    20.Steers WD, Kolbeck S, Creedon D, Tuttle JB. Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest. 1991;88(5):1709–15.PubMed PubMedCentral CrossRef
    21.Liu HT, Kuo HC. Increased urine and serum nerve growth factor levels in interstitial cystitis suggest chronic inflammation is involved in the pathogenesis of disease. PLoS One. 2012;7(9), e44687.PubMed PubMedCentral CrossRef
    22.Cruz CD. Neurotrophins in bladder function: what do we know and where do we go from here? NeurourolUrodyn. 2014;33(1):39–45.
    23.Rachaneni S, Arya P, Latthe P. Urinary nerve growth factor: a biomarker of detrusor overactivity? A systematic review. Int urogynecol j. 2013;24(10):1603–9.PubMed CrossRef
    24.Seth JH, Sahai A, Khan MS, van der Aa F, de Ridder D, Panicker JN, et al. Nerve growth factor (NGF): a potential urinary biomarker for overactive bladder syndrome (OAB)? BJU Int. 2013;111(3):372–80.PubMed CrossRef
    25.Ceron JJ, Eckersall PD, Martynez-Subiela S. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet clin pathol/American society for veterinary clinical pathology. 2005;34(2):85–99.CrossRef
    26.Chuang Y-C, Tyagi V, Liu R-T, Chancellor MB, Tyagi P. Urine and serum c-reactive protein levels as potential biomarkers of lower urinary tract symptoms. Urological science (previously Journal of Taiwan urological association). 2010;21(3):132–6.
    27.Hsiao SM, Lin HH, Kuo HC. The role of serum c-reactive protein in women with lower urinary tract symptoms. Int urogynecol j. 2012;23(7):935–40.PubMed CrossRef
    28.Seo KW, Lee JB, Ahn JO, Lee HW, Hwang CY, Youn HY, et al. C-reactive protein as an indicator of inflammatory responses to experimentally induced cystitis in dogs. J Vet Sci. 2012;13(2):179–85.PubMed PubMedCentral CrossRef
    29.Bathen-Noethen A, Carlson R, Menzel D, Mischke R, Tipold A. Concentrations of acute-phase proteins in dogs with steroid responsive meningitis-arteritis. J vet int med / American college of veterinary internal medicine. 2008;22(5):1149–56.CrossRef
    30.Isola M, Ferrari V, Miolo A, Stabile F, Bernardini D, Carnier P, et al. Nerve growth factor concentrations in the synovial fluid from healthy dogs and dogs with secondary osteoarthritis. Vet Comp Orthop Traumatol. 2011;24(4):279–84.PubMed CrossRef
    31.Aloe L, Bracci-Laudiero L, Bonini S, Manni L, Aloe L. The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases. Allergy. 1997;52(9):883–994.PubMed CrossRef
    32.Liu H-T, Liu A-B, Chancellor MB, Kuo H-C. Urinary nerve growth factor level is correlated with the severity of neurological impairment in patients with cerebrovascular accident. BJU Int. 2009;104(8):1158–62.PubMed CrossRef
    33.Liu H-T, Kuo H-C. Urinary nerve growth factor levels are elevated in patients with overactive bladder and do not significantly increase with bladder distention. NeurourolUrodyn. 2009;28(1):78–81.
    34.Vizzard MA. Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction. Exp Neurol. 2000;161(1):273–84.PubMed CrossRef
    35.Martinez-Subiela S, Garcia-Martinez JD, Tvarijonaviciute A, Tecles F, Caldin M, Bernal LJ, et al. Urinary C reactive protein levels in dogs with leishmaniasis at different stages of renal damage. Res Vet Sci. 2013;95(3):924–9.PubMed CrossRef
    36.Defauw P, Schoeman JP, Smets P, Goddard A, Meyer E, Liebenberg C, et al. Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi. Vet Parasitol. 2012;190(3–4):326–32.PubMed CrossRef
    37.Maddens B, Heiene R, Smets P, Svensson M, Aresu L, van der Lugt J, et al. Evaluation of kidney injury in dogs with pyometra based on proteinuria, renal histomorphology, and urinary biomarkers. J vet int med / American college of veterinary internal medicine. 2011;25(5):1075–83.CrossRef
    38.Yasojima K, Schwab C, McGeer EG, McGeer PL. Human neurons generate c-reactive protein and amyloid P: upregulation in Alzheimer's disease. Brain Res. 2000;887(1):80–9.PubMed CrossRef
    39.Black S, Kushner I, Samols D. C-reactive Protein. J Biol Chem. 2004;279(47):48487–90.PubMed CrossRef
    40.Calabro P, Willerson JT, Yeh ET. Inflammatory cytokines stimulated c-reactive protein production by human coronary artery smooth muscle cells. Circulation. 2003;108(16):1930–2.PubMed CrossRef
    41.Yamamoto S, Shida T, Miyaji S, Santsuka H, Fujise H, Mukawa K, et al. Changes in serum c-reactive protein levels in dogs with various disorders and surgical traumas. Vet Res Commun. 1993;17(2):85–93.PubMed CrossRef
    42.Otabe K, Sugimoto T, Jinbo T, Honda M, Kitao S, Hayashi S, et al. Physiological levels of C-reactive protein in normal canine sera. Vet Res Commun. 1998;22(2):77–85.PubMed CrossRef
    43.Kjelgaard-Hansen M, Strom H, Mikkelsen LF, Eriksen T, Jensen AL, Luntang-Jensen M. Canine serum C-reactive protein as a quantitative marker of the inflammatory stimulus of aseptic elective soft tissue surgery. Vet clin pathol/American society for veterinary clinical pathology. 2013;42(3):342–5.CrossRef
    44.Sharp NJH, Wheeler SJ. Small animal spinal disorders. 2nd ed. Edinburgh, London: Elsevier Mosby; 2005. p. 41–159.CrossRef
  • 作者单位:Ulrike Kordass (1)
    Regina Carlson (1)
    Veronika Maria Stein (1)
    Andrea Tipold (1)

    1. Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany
  • 刊物主题:Veterinary Medicine; Zoology; Transgenics;
  • 出版者:BioMed Central
  • ISSN:1746-6148
文摘
Background The purpose of this study was to prove the hypothesis that C-reactive protein (CRP) and nerve growth factor (NGF) may be potential biomarkers for lower urinary tract disorders and may be able to distinguish between micturition dysfunctions of different origin in dogs with spinal cord diseases. NGF- and CRP- concentrations were measured in serum and urine samples using specific ELISA-Kits. Results in urine were standardized by urine-creatinine levels.
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