l-Theanine extends lifespan of adult Caenorhabditis elegans

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• 作者：Kim Zarse (1)
  Saskia Jabin (1)
  Michael Ristow (12) mr@mristow.org
• 关键词：Amino acids &#8211 ; Aging &#8211 ; Anti ; aging &#8211 ; Lifespan &#8211 ; Signaling &#8211 ; Pharmacology &#8211 ; Nutrition &#8211 ; Nutrients &#8211 ; Phytochemicals &#8211 ; Tea &#8211 ; Model organisms &#8211 ; Metazoans &#8211 ; Nematodes &#8211 ; Caenorhabditis elegans &#8211 ; Calorie restriction mimetics &#8211 ; Exercise mimetics &#8211 ; Hormesis &#8211 ; Mitohormesis
• 刊名：European Journal of Nutrition
• 出版年：2012
• 出版时间：September 2012
• 年：2012
• 卷：51
• 期：6
• 页码：765-768
• 全文大小：227.0 KB
• 参考文献：1. Zarse K, Bossecker A, Muller-Kuhrt L, Siems K, Hernandez MA, Berendsohn WG, Birringer M, Ristow M (2011) The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans. Horm Metab Res 43(4):241–243
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  8. Zarse K, Ristow M (2008) Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans. PLoS ONE 3(12):e4062
  9. Zarse K, Schmeisser S, Birringer M, Falk E, Schmoll D, Ristow M (2010) Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans. Horm Metab Res 42(12):837–839
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• 作者单位：1. Department of Human Nutrition, Institute of Nutrition, University of Jena, 07743 Jena, Germany2. Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbr眉cke, 14558 Nuthetal, Germany
• ISSN：1436-6215

文摘

Purpose Compounds that delay aging in model organisms may be of significant interest to anti-aging medicine, since these substances potentially provide pharmaceutical approaches to promote healthy lifespan in humans. We here aimed to test whether pharmaceutical concentrations of l-theanine, a putative anti-cancer, anti-obesity, blood pressure-lowering, and neuroprotective compound contained in green tea (Camellia sinensis), are capable of extending lifespan in a nematodal model organism for aging processes, the roundworm Caenorhabditis elegans.