Influence of differentially expressed genes from suicide post-mortem study on personality traits as endophenotypes on healthy subjects and suicide attempters

详细信息    查看全文

• 作者：Raffaella Calati (1)
  Ina Giegling (2)
  Martina Balestri (3)
  Niki Antypa (3)
  Marion Friedl (2)
  Bettina Konte (2)
  Annette M. Hartmann (2)
  Alessandro Serretti (3)
  Dan Rujescu (2)
  
• 关键词：Genetics ; Personality ; Suicide ; Genetic association studies
• 刊名：European Archives of Psychiatry and Clinical Neuroscience
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：264
• 期：5
• 页码：423-432
• 全文大小：402 KB
• 参考文献：1. WHO (2000) Health systems: improving performance. World Health Organization, Geneva
  2. Levi F et al (2003) Trends in mortality from suicide, 1965-9. Acta Psychiatr Scand 108(5):341-49 CrossRef
  3. Mann JJ (2003) Neurobiology of suicidal behaviour. Nat Rev Neurosci 4(10):819-28 CrossRef
  4. Roy A (1993) Genetic and biologic risk factors for suicide in depressive disorders. Psychiatr Q 64(4):345-58 CrossRef
  5. Statham DJ et al (1998) Suicidal behaviour: an epidemiological and genetic study. Psychol Med 28(4):839-55 CrossRef
  6. Brent DA, Mann JJ (2005) Family genetic studies, suicide, and suicidal behavior. Am J Med Genet C Semin Med Genet 133C(1):13-4 CrossRef
  7. Roy A, Segal NL, Sarchiapone M (1995) Attempted suicide among living co-twins of twin suicide victims. Am J Psychiatry 152(7):1075-076
  8. McGuffin P, Marusic A, Farmer A (2001) What can psychiatric genetics offer suicidology? Crisis 22(2):61-5 CrossRef
  9. Rujescu D et al (2007) Molecular genetic findings in suicidal behavior: what is beyond the serotonergic system? Arch Suicide Res 11(1):17-0 CrossRef
  10. Asberg M, Traskman L, Thoren P (1976) 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33(10):1193-197 CrossRef
  11. Mann JJ, Malone KM (1997) Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biol Psychiatry 41(2):162-71 CrossRef
  12. Lidberg L et al (2000) Suicide attempts and impulse control disorder are related to low cerebrospinal fluid 5-HIAA in mentally disordered violent offenders. Acta Psychiatr Scand 101(5):395-02 CrossRef
  13. Rujescu D, Giegling I (2010) The genetics of neurosystems in mental ill-health and suicidality: beyond serotonin. Eur Psychiatry 25(5):272-74 CrossRef
  14. Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160(4):636-45 CrossRef
  15. Kendler KS, Neale MC (2010) Endophenotype: a conceptual analysis. Mol Psychiatry 15(8):789-97 CrossRef
  16. Brezo J, Paris J, Turecki G (2006) Personality traits as correlates of suicidal ideation, suicide attempts, and suicide completions: a systematic review. Acta Psychiatr Scand 113(3):180-06 CrossRef
  17. Mann JJ et al (2009) Candidate endophenotypes for genetic studies of suicidal behavior. Biol Psychiatry 65(7):556-63 CrossRef
  18. Bouchard TJ Jr, Loehlin JC (2001) Genes, evolution, and personality. Behav Genet 31(3):243-73 CrossRef
  19. Rujescu D, Giegling I (2012) Intermediate phenotypes in suicidal behavior focus on personality. In: Dwivedi Y (ed) The neurobiological basis of suicide, Chap 18. CRC Press, Boca Raton, FL
  20. Rothenhausler HB, Stepan A, Kapfhammer HP (2006) Soluble interleukin 2 receptor levels, temperament and character in formerly depressed suicide attempters compared with normal controls. Suicide Life Threat Behav 36(4):455-66 CrossRef
  21. Becerra B et al (2005) Temperament and character profile of persons with suicide attempt. Actas Esp Psiquiatr 33(2):117-22
  22. Favaro A et al (2008) Self-injurious behavior and attempted suicide in purging bulimia nervosa: associations with psychiatric comorbidity. J Affect Disord 105(1-):285-89 CrossRef
  23. Evren C, Evren B (2006) The relationship of suicide attempt history with childhood abuse and neglect, alexithymia and temperament and character dimensions of personality in substance dependents. Nord J Psychiatry 60(4):263-69 CrossRef
  24. Thalmeier A et al (2008) Gene expression profiling of post-mortem orbitofrontal cortex in violent suicide victims. Int J Neuropsychopharmacol 11(2):217-28 CrossRef
  25. Harris MA et al. (2004) The gene ontology (GO) database and informatics resource. Nucleic Acids Res 32(Database issue):D258–D261
  26. Pierce DW (1981) The predictive validation of a suicide intent scale: a five year follow-up. Br J Psychiatry 139:391-96 CrossRef
  27. First MB et al (1990) Structured clinical interview for DSM-IV axis II personality disorders (SCID-II). Biometrics Research Department, New York State Psychiatric Institute, New York
  28. First MB et al (1995) Structured clinical interview for DSM-IV axis I disorders—patient edition (SCID-I/P, Version 2.0). Biometrics Research Department, New York State Psychiatric Institute, New York
  29. Calati R et al (2008) Temperament and character of suicide attempters. J Psychiatr Res 42(11):938-45 CrossRef
  30. Giegling I et al (2006) Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene. J Affect Disord 96(1-):75-1 CrossRef
  31. Serretti A et al (2007) 5-HT2A SNPs and the temperament and character inventory. Prog Neuropsychopharmacol Biol Psychiatry 31(6):1275-281 CrossRef
  32. Serretti A et al (2009) Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls. J Psychiatr Res 43(5):519-25 CrossRef
  33. Giegling I et al (2009) Personality and attempted suicide. Analysis of anger, aggression and impulsivity. J Psychiatr Res 43(16):1262-271 CrossRef
  34. Cloninger CR et al (1994) The temperament and character inventory (TCI): a guide to its development and use. Center for Psychobiology of Personality Washington University, St. Louis, Missouri
  35. Cloninger CR, Svrakic DM, Przybeck TR (1993) A psychobiological model of temperament and character. Arch Gen Psychiatry 50(12):975-90 CrossRef
  36. Brandstrom S, Richter J, Nylander PO (2003) Further development of the Temperament and Character Inventory. Psychol Rep 93(3 Pt 2):995-002 CrossRef
  37. Rujescu D et al (2003) A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Biol Psychiatry 54(1):34-9 CrossRef
  38. Barrett JC et al (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263-65 CrossRef
  39. Gabriel SB et al (2002) The structure of haplotype blocks in the human genome. Science 296(5576):2225-229 CrossRef
  40. StatSoft I (1995) STATISTICA per windows
  41. Faul F (2007) G*Power. Universitat Kiel, Germany
  42. Cohen J (1988) Statistical power analysis for the behavioral sciences. Lawrence Erlbaum Associates, Hillsdale, NJ, pp 8-4
  43. Lecka-Czernik B, Lumpkin CK Jr, Goldstein S (1995) An overexpressed gene transcript in senescent and quiescent human fibroblasts encoding a novel protein in the epidermal growth factor-like repeat family stimulates DNA synthesis. Mol Cell Biol 15(1):120-28
  44. Togashi H et al (2002) Cadherin regulates dendritic spine morphogenesis. Neuron 35(1):77-9 CrossRef
  45. Marijnissen G et al (2002) The temperament and character inventory in major depression. J Affect Disord 70(2):219-23 CrossRef
  46. Farmer A et al (2003) A sib-pair study of the Temperament and Character Inventory scales in major depression. Arch Gen Psychiatry 60(5):490-96 CrossRef
  47. Celikel FC et al (2009) Cloninger’s temperament and character dimensions of personality in patients with major depressive disorder. Compr Psychiatry 50(6):556-61 CrossRef
  48. Jylha P et al (2011) Differences in temperament and character dimensions in patients with bipolar I or II or major depressive disorder and general population subjects. Psychol Med 41(8):1579-591 CrossRef
  49. Ekinci O, Albayrak Y, Ekinci AE (2012) Temperament and character in euthymic major depressive disorder patients: the effect of previous suicide attempts and psychotic mood episodes. Psychiatry Investig 9(2):119-26 CrossRef
  50. Fassino S et al (2009) Personality trait interactions in parents of patients with borderline personality disorder: a controlled study using the Temperament and Character Inventory. Psychiatry Res 165(1-):128-36 CrossRef
  51. Svrakic DM et al (1993) Differential diagnosis of personality disorders by the seven-factor model of temperament and character. Arch Gen Psychiatry 50(12):991-99 CrossRef
  52. Sarisoy G et al. (2012) Temperament and character traits in patients with bipolar disorder and associations with attempted suicide. Compr Psychiatry 53(8):1096-102 CrossRef
  53. Conrad R et al (2009) Temperament and character personality profile in relation to suicidal ideation and suicide attempts in major depressed patients. Psychiatry Res 170(2-):212-17 CrossRef
  54. Csorba J et al (2010) Novelty seeking: difference between suicidal and non-suicidal Hungarian adolescent outpatients suffering from depression. J Affect Disord 120(1-):217-20 CrossRef
  55. Albayrak Y, Ekinci O, Caykoylu A (2012) Temperament and character personality profile in relation to suicide attempts in patients with schizophrenia. Compr Psychiatry 53(8):1130-136 CrossRef
  56. Sayin A et al (2007) Relation of temperament and character properties with clinical presentation of bipolar disorder. Compr Psychiatry 48(5):446-51 CrossRef
  57. Aukst Margetic B et al. (2012) Current suicidality and previous suicidal attempts in patients with schizophrenia are associated with different dimensions of temperament and character. Psychiatry Res 200(2-):120-25 CrossRef
  58. Carballo E, Lai WS, Blackshear PJ (1998) Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281(5379):1001-005 CrossRef
  59. Al-Souhibani N et al (2010) The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes. Oncogene 29(29):4205-215 CrossRef
  60. De Fruyt F, Van De Wiele L, Van Heeringen C (2000) Cloninger’s psychobiological model of temperament and character and the five-factor model of personality. Pers Individ Differ 29:441-52 CrossRef
  61. Sutin AR et al (2010) High neuroticism and low conscientiousness are associated with interleukin-6. Psychol Med 40(9):1485-493 CrossRef
  62. Bouhuys AL et al (2004) Potential psychosocial mechanisms linking depression to immune function in elderly subjects. Psychiatry Res 127(3):237-45 CrossRef
  63. Capuron L et al (2011) Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation. Psychol Med 41(7):1517-528 CrossRef
  64. Roy B et al (2010) Association of optimism and pessimism with inflammation and hemostasis in the Multi-Ethnic Study of Atherosclerosis (MESA). Psychosom Med 72(2):134-40 CrossRef
  65. Jonassaint CR et al (2010) Personality and inflammation: the protective effect of openness to experience. Ethn Dis 20(1):11-4
  66. Chapman BP et al (2011) Openness and conscientiousness predict 34-week patterns of Interleukin-6 in older persons. Brain Behav Immun 25(4):667-73 CrossRef
  67. Brandstrom S, Richter J, Przybeck T (2001) Distributions by age and sex of the dimensions of temperament and character inventory in a cross-cultural perspective among Sweden, Germany, and the USA. Psychol Rep 89(3):747-58 CrossRef
  68. Cavalli Sforza L, History The (1994) Geography of Human Genes. Princeton University Press, Princeton, NJ
  69. Strakowski SM et al (1992) Possible affective-state dependence of the Tridimensional Personality Questionnaire in first-episode psychosis. Psychiatry Res 41(3):215-26 CrossRef
  70. Richter J, Eisemann M, Richter G (2000) Temperament and character during the course of unipolar depression among inpatients. Eur Arch Psychiatry Clin Neurosci 250(1):40-7 CrossRef
  71. Ohi K et al. (2012) Personality traits and schizophrenia: evidence from a case-control study and meta-analysis. Psychiatry Res 198(1):7-1 CrossRef
  72. Jetha MK, Goldberg JO, Schmidt LA (2012) Temperament and its relation to social functioning in schizophrenia. Int J Soc Psychiatry 59(3):254-63 CrossRef
  73. Neuner T et al (2008) Predicting inpatient suicides and suicide attempts by using clinical routine data? Gen Hosp Psychiatry 30(4):324-30 CrossRef
  
• 作者单位：Raffaella Calati (1)
  Ina Giegling (2)
  Martina Balestri (3)
  Niki Antypa (3)
  Marion Friedl (2)
  Bettina Konte (2)
  Annette M. Hartmann (2)
  Alessandro Serretti (3)
  Dan Rujescu (2)
  
  1. IRCCS Centro S. Giovanni di Dio, Fatebenefratelli, Brescia, Italy
  2. Department of Psychiatry, University of Halle, Halle, Germany
  3. Department of Biomedical and NeuroMotor Sciences, University of Bologna, Viale Carlo Pepoli 5, 40123, Bologna, Italy
  
• ISSN：1433-8491

文摘

Although a genetic contribution to the complex aetiology of suicidal behaviour has been suggested since many years, the attempt to identify specific genes related to suicide has led to contrasting results. In a post-mortem study on suicide, we previously detected several differentially expressed genes which, however, have not been subsequently associated with suicidal behaviour, or only nominally. Therefore, personality traits may represent good intermediate endophenotypes. Our primary aim was to investigate the potential modulation of several single-nucleotide polymorphisms (SNPs) of the same previously investigated genes (S100A13, EFEMP1, PCDHB5, PDGFRB, CDCA7L, SCN2B, PTPRR, MLC1 and ZFP36) on personality traits, as measured with the Temperament and Character Inventory (TCI), in a German sample composed of 287 healthy subjects (males: 123, 42.9?%; mean age: 45.2?±?14.9?years) and in 111 psychiatric patients who attempted suicide (males: 43, 38.6?%; mean age: 39.2?±?13.6?years). Multivariate analysis of covariance was used to test possible influence of single SNPs on TCI scores. Genotypic, allelic and haplotypic analyses have been performed. Controlling for sex, age and educational level, genotypic analyses showed a modulation of EFEMP1 rs960993 and rs2903838 polymorphisms on both harm avoidance and self-directedness in healthy subjects. Interestingly, we could replicate these associations in haploblocks within controls (p?p?SNPs, never investigated in association with suicidal behaviour and related personality, could be involved in its modulation in healthy subjects as well as in suicide attempters.