Spatiotemporal distribution modeling of PET tracer uptake in solid tumors

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• 作者：Madjid Soltani ; Mostafa Sefidgar ; Hossein Bazmara…
• 关键词：Positron emission tomography ; Solid tumors ; Kinetic modeling ; Spatiotemporal modeling ; Convection–diffusion–reaction equations
• 刊名：Annals of Nuclear Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：2
• 页码：109-124
• 全文大小：
• 刊物主题：Nuclear Medicine; Imaging / Radiology;
• 出版者：Springer Japan
• ISSN：1864-6433
• 卷排序：31

文摘

ObjectiveDistribution of PET tracer uptake is elaborately modeled via a general equation used for solute transport modeling. This model can be used to incorporate various transport parameters of a solid tumor such as hydraulic conductivity of the microvessel wall, transvascular permeability as well as interstitial space parameters. This is especially significant because tracer delivery and drug delivery to solid tumors are determined by similar underlying tumor transport phenomena, and quantifying the former can enable enhanced prediction of the latter.