CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model

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• 作者：Xuan Sun ; Danielle J. Glynn ; Leigh J. Hodson ; Cecilia Huo…
• 关键词：Mammary gland ; Development ; Macrophage ; Chemokine (C ; C motif) ligand 2 ; Mouse model ; Mammographic density
• 刊名：Breast Cancer Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：19
• 期：1
• 全文大小：1892KB
• 刊物主题：Cancer Research; Oncology; Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1465-542X
• 卷排序：19

文摘

BackgroundMacrophages play diverse roles in mammary gland development and breast cancer. CC-chemokine ligand 2 (CCL2) is an inflammatory cytokine that recruits macrophages to sites of injury. Although CCL2 has been detected in human and mouse mammary epithelium, its role in regulating mammary gland development and cancer risk has not been explored.