Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion

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• 作者：Jamie A. Whitelaw ; Fernanda Latorre-Barragan ; Simon Gras ; Gurman S. Pall…
• 关键词：Actin ; Myosin ; Motility ; Attachment ; Toxoplasma ; Apicomplexa ; Host cell invasion ; Membrane flow
• 刊名：BMC Biology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：10724KB
• 刊物主题：Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1741-7007
• 卷排序：15

文摘

BackgroundApicomplexan parasites employ a unique form of movement, termed gliding motility, in order to invade the host cell. This movement depends on the parasite’s actomyosin system, which is thought to generate the force during gliding. However, recent evidence questions the exact molecular role of this system, since mutants for core components of the gliding machinery, such as parasite actin or subunits of the MyoA-motor complex (the glideosome), remain motile and invasive, albeit at significantly reduced efficiencies. While compensatory mechanisms and unusual polymerisation kinetics of parasite actin have been evoked to explain these findings, the actomyosin system could also play a role distinct from force production during parasite movement.