Well-differentiated pancreatic ductal adenocarcinomas measuring ??cm exhibit early features of tumor progression: a report of five lesions and a comparative study with advanced lesions

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• 作者：Sadanobu Izumi ; Satoko Nakamura ; Shohei Mano ; Yuji Onoda
• 关键词：Pancreatic ductal adenocarcinoma ; Early pancreatic cancer ; Small pancreatic cancer ; Desmoplasia ; Molecular abnormalities
• 刊名：Surgery Today
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：44
• 期：11
• 页码：2058-2064
• 全文大小：1,246 KB
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• 作者单位：Sadanobu Izumi (1)
  Satoko Nakamura (2)
  Shohei Mano (2)
  Yuji Onoda (1)
  
  1. Department of Gastroenterological Surgery, Kagawa Prefectural Central Hospital, 5-4-16 Banchou, Takamatsu, Kagawa, 760-8557, Japan
  2. Department of Pathology, Kagawa Prefectural Central Hospital, Takamatsu, Japan
  
• ISSN：1436-2813

文摘

Purpose The purpose of this study was to clarify whether the features of well-differentiated pancreatic ductal adenocarcinomas (PDACs) measuring ??cm are the same as those of early PDACs. Methods Five well-differentiated PDACs measuring ??cm were clinicopathologically compared with 19?≥??cm PDACs. Additionally, an immunohistochemical analysis for abnormalities in the expression of five molecular parameters: MUC1, p16, p53, Smad4 and sonic hedgehog, which are associated with tumor progression, was performed. Results The clinicopathological comparison revealed that well-differentiated PDACs measuring ??cm were detected significantly more often without angiolymphatic invasion and with a sparse presence of cancer cells than were the ??cm PDACs. On the other hand, in well-differentiated PDACs measuring ??cm, the incidence of abnormal immunolabeling for MUC1, p16, p53 and sonic hedgehog was similar to that in ??cm PDACs. However, the incidence of diffusely positive immunolabeling for MUC1 and the mean number of abnormally immunolabeled samples for the five parameters were significantly lower in well-differentiated ??cm PDACs (20?% and 3?±?1) than in ??cm PDACs (90?% and 4?±?1). Conclusion The current study revealed that as the tumor size increases, molecular abnormalities are accumulated, suggesting that well-differentiated PDACs measuring ??cm are in an earlier stage of genetic progression than are ??cm PDACs, and these lesions may exhibit early features of invasive PDACs.