Investigation of the Cytotoxic Effects of Titanate Nanotubes on Caco-2 Cells

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• 作者：Ferenc Fenyvesi (1)
  Zoltán Kónya (2)
  Zsolt Rázga (3)
  Miklós Vecsernyés (1)
  Péter Kása Jr. (4)
  Klára Pintye-Hódi (4)
  Ildikó Bácskay (1)
  
• 关键词：Caco ; 2 cells ; cytotoxicity ; titanate nanotubes
• 刊名：AAPS PharmSciTech
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：15
• 期：4
• 页码：858-861
• 全文大小：649 KB
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• 作者单位：Ferenc Fenyvesi (1)
  Zoltán Kónya (2)
  Zsolt Rázga (3)
  Miklós Vecsernyés (1)
  Péter Kása Jr. (4)
  Klára Pintye-Hódi (4)
  Ildikó Bácskay (1)
  
  1. Department of Pharmaceutical Technology, University of Debrecen, 4010, Debrecen, Nagyerdei krt. 98, Hungary
  2. Department of Applied and Environmental Chemistry, University of Szeged and MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, 6720, Szeged, Rerrich ter 1, Hungary
  3. Department of Pathology, University of Szeged, 6725, Szeged, állomás utca 2, Hungary
  4. Department of Pharmaceutical Technology, University of Szeged, 6720, Szeged, E?tv?s utca 6, Hungary
  
• ISSN：1530-9932

文摘

Titanate nanotubes can be used as drug delivery systems, but limited information is available on their interactions with intestinal cells. In this study, we investigated the cytotoxicity and cellular uptake of titanate nanotubes on Caco-2 monolayers and found that up to 5?mg/ml concentration, these nanotubes are not cytotoxic and not able to permeate through the intestinal cell layer. Transmission electron microscopic experiments showed that titanate nanotubes are not taken up by cells, only caused a high-density granulation on the surface of the endoplasmic reticulum. According to these results, titanate nanotubes are suitable systems for intestinal drug delivery.