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Identification of a Ly-6 superfamily gene expressed in lateral line neuromasts in zebrafish
- 作者：Dongrui Ji ; Lingyi Li ; Shicui Zhang ; Hongyan Li
- 关键词：Lateral line ; Ly ; 6 ; Neuromast ; Zebrafish
- 刊名：Development Genes and Evolution
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：225
- 期：1
- 页码：47-53
- 全文大小：7,499 KB
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14. Ji D, Liu P, Wang F, Zhang S, Li H (2012) Identification and expression of a novel member of Ly-6 superfamily in zebrafish / Danio rerio. Dev Genes Evol 222:119-24. doi:10.1007/s00427-012-0393-9 - 作者单位：Dongrui Ji (1) (2)
Lingyi Li (1) (2)
Shicui Zhang (1) (2)
Hongyan Li (1) (2)
1. Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, 266003, China
2. Laboratory for Evolution & Development, Department of Marine Biology, Ocean University of China, Room 301, 5 Yushan Road, Qingdao, 266003, China
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Developmental Biology
Neurosciences
Cell Biology
- 出版者：Springer Berlin / Heidelberg
- ISSN：1432-041X
文摘
Lymphocyte antigen-6 (Ly-6) superfamily members have been identified in zebrafish, but the expression and function of these Ly-6 genes remain largely unknown. Posterior lateral line (pLL) system is produced by migrating pLL primordium (pLLp). Chemokine signaling, Notch, Wnt, and fibroblast growth factor (FGF) signaling regulate migration of pLLp cells and formation of neuromasts. However, the mechanism of neuromast deposition remains to be explored. Identification of novel genes expressed in pLLp will certainly help the study of such a process. Here we identified a Ly-6 gene called neuromast-expressed gpi-anchored lymphocyte antigen-6 (negaly6), which was specifically expressed in neuromast. Quantitative real-time PCR (qRT-PCR) analysis showed that negaly6 started to be expressed at 24?hpf, and whole-mount in situ hybridization analysis indicated that negaly6 was highly expressed in the trailing zone of pLLp and mature neuromast. Furthermore, negaly6 expression was inhibited by FGF signaling antagonist but not by Wnt signaling agonist or antagonist. Collectively, these data indicate that negaly6 may be associated with the regulation of neuromast deposition via FGF signaling pathway.
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