Partial bladder outlet obstruction is associated with decreased expression and function of the small-conductance Ca²⁺-activated K⁺ channel in guinea pig detrusor smooth muscle

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• 作者：Ning Li ; Xiaoning He ; Zizheng Li ; Yili Liu…
• 关键词：SK channel ; NS309 ; Partial bladder outlet obstruction
• 刊名：International Urology and Nephrology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：1
• 页码：17-26
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Nephrology; Urology;
• 出版者：Springer Netherlands
• ISSN：1573-2584
• 卷排序：49

文摘

PurposePartial bladder outlet obstruction (PBOO) usually induces overactive bladder (OAB) associated with detrusor overactivity (DO) which is related to the increased contractility of detrusor smooth muscle (DSM). The pharmacological activation of small-conductance Ca2+-activated K+ (SK) channels dramatically attenuates DSM contractility. However, the role of SK channels in the PBOO DSM is less clear. Here, we tested the hypothesis that PBOO is associated with decreased expression and function of SK channels in DSM and that the activation of SK channels is a potential target to regulate DO.