Neuron Emulator Implementations for Patch-Clamp and Longitudinal Electrode Settings

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• 作者：Robert Rieger ; Ying Sun ; Yen Cheng Wu
• 关键词：Neuron emulation ; Hardware emulator ; Action potential (AP) ; Patch ; clamp ; Nerve response ; Cuff ; electrode recording ; Electronic circuit
• 刊名：Journal of Medical and Biological Engineering
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：36
• 期：4
• 页码：563-572
• 全文大小：1,533 KB
• 刊物类别：Biomedical Engineering; Cell Biology; Imaging / Radiology;
• 刊物主题：Biomedical Engineering; Cell Biology; Imaging / Radiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：2199-4757
• 卷排序：36

文摘

This paper describes the implementation of two neuron emulator circuits. The first circuit provides the electrical properties of a neuron as seen from a single patch-clamp electrode with a defined action potential (AP) charge output and the second circuit offers multi-channel output with an adjustable phase delay that provides responses typically seen by a longitudinal electrode (e.g., peripheral nerve cuff or intraneural electrode) using a 3 × 4 cm2 prototype board. The emulators are intended for testing electrophysiological equipment such as patch-clamp amplifiers and multi-channel devices. APs are generated with a voltage-dependent frequency controlled by a microcontroller. The reported measured results confirm the capability of performing voltage-clamp and rate-responsive current-clamp techniques and generating phase-delayed AP outputs, respectively.