Grading von Weichgewebe- und Knochensarkomen

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• 作者：Prof. Dr. I. Petersen ; E. Wardelmann
• 刊名：Der Pathologe
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：37
• 期：4
• 页码：320-327
• 全文大小：769 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1963
• 卷排序：37

文摘

Malignancy grading is an essential element in the classification of sarcomas. It correlates with the prognosis of the disease and the risk of metastasis. This article presents the grading schemes for soft tissue, bone and pediatric sarcomas. It summarizes the histological criteria of the Federation Nationale des Centres de Lutte Contre le Cancer (FNCLCC) system and the Pediatric Oncology Group as well as the grading of bone tumors by the College of American Pathologists (CAP). Furthermore, the potential relevance of gene expression signatures, the complexity index in sarcoma (CINSARC) and single genetic alterations (p53, MDM2, p16, SWI/SNF, EWSR1 fusions and PAX3/PAX7-FOXO1 fusions) for the prognosis of sarcomas are discussed.KeywordsSarcomaMetastasisClassificationPrognosisMutation