Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging

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• 作者：Milos Petrik (15) milospetrik@seznam.cz
  Gerben M. Franssen (2)
  Hubertus Haas (3)
  Peter Laverman (2)
  Caroline H?rtnagl (4)
  Markus Schrettl (3)
  Anna Helbok (1)
  Cornelia Lass-Fl?rl (4)
  Clemens Decristoforo (1) clemens.decristoforo@uki.at
• 关键词：68Ga ; siderophores – Aspergillus fumigatus – Invasive aspergillosis – Infection imaging
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2012
• 出版时间：July 2012
• 年：2012
• 卷：39
• 期：7
• 页码：1175-1183
• 全文大小：439.3 KB
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• 作者单位：1. Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria2. Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands3. Division of Molecular Biology/Biocenter, Innsbruck Medical University, Innsbruck, Austria4. Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical University, Innsbruck, Austria5. Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, Palacky University, Olomouc, Czech Republic
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Nuclear Medicine
  Imaging and Radiology
  Orthopedics
  Cardiology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1619-7089

文摘

Purpose Invasive pulmonary aspergillosis is mainly caused by Aspergillus fumigatus, and is one of the major causes of morbidity and mortality in immunocompromised patients. The mortality associated with invasive pulmonary aspergillosis remains high, mainly due to the difficulties and limitations in diagnosis. We have shown that siderophores can be labelled with 68Ga and can be used for PET imaging of A. fumigatus infection in rats. Here we report on the further evaluation of the most promising 68Ga-siderophore candidates, triacetylfusarinine (TAFC) and ferrioxamine E (FOXE).