Discovery of new coumarin substituted quinazolines as potential bioactive agents

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• 作者：Amit B. Patel ; Rinku M. Raval
• 关键词：Quinazoline ; Coumarin ; Benzothiazole ; Antimicrobial ; Antimycobacterial activity
• 刊名：Research on Chemical Intermediates
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：42
• 期：3
• 页码：2163-2175
• 全文大小：425 KB
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• 作者单位：Amit B. Patel (1)
  Rinku M. Raval (2)
  
  1. Department of Chemistry, Government College Daman, Daman, 396210, UT, India
  2. Department of Chemistry, HVHP Institute of PG Studies and Research, KSV, Kadi, 382715, India
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1568-5675

文摘

In view of the biological importance of some important pharmacophores such as quinazoline, coumarin, and benzothiazole, we frame these moieties in a single molecular scaffold to be screened in vitro for their antimicrobial activity. The newly synthesized analogs have been examined for their in vitro biological efficacy against two Gram-positive bacteria, three Gram-negative bacteria, two fungi, and for antimycobacterial activity against M. tuberculosis H₃₇Rv. The bioassay results revealed that the majority of final analogs exhibited potential bio efficacies with the remarkable level of MICs comparable to control drugs. The new synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, and MS analysis.