5-aminolevulinic acid combined with ferrous ion reduces adiposity and improves glucose tolerance in diet-induced obese mice via enhancing mitochondrial function

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• 作者：Urara Ota ; Takeshi Hara ; Hitoshi Nakagawa ; Emi Tsuru…
• 关键词：5 ; aminolevulinic acid ; Diet ; induced obese mice ; Glucose tolerance ; Glucose uptake ; Mitochondrial oxidative phosphorylation complex ; Obesity ; White adipose tissue
• 刊名：BMC Pharmacology and Toxicology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：1242KB
• 刊物主题：Pharmacology/Toxicology;
• 出版者：BioMed Central
• ISSN：2050-6511
• 卷排序：18

文摘

BackgroundMitochondrial dysfunction is associated with obesity and various obesity-associated pathological conditions including glucose intolerance. 5-Aminolevulinic acid (ALA), a precursor of heme metabolites, is a natural amino acid synthesized in the mitochondria, and various types of cytochromes containing heme contribute to aerobic energy metabolism. Thus, ALA might have beneficial effects on the reduction of adiposity and improvement of glucose tolerance through its promotion of heme synthesis. In the present study, we investigated the effects of ALA combined with sodium ferrous citrate (SFC) on obesity and glucose intolerance in diet-induced obese mice.