Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease

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• 作者：Xuelin Zhang ; Yang Wang ; Pingsheng Liu
• 关键词：non ; alcoholic fatty liver disease ; lipid droplets ; genome ; wide association study ; proteomics ; PNPLA3 ; 17β ; HSD13
• 刊名：Protein & Cell
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：4-13
• 全文大小：498KB
• 刊物主题：Biochemistry, general; Protein Science; Cell Biology; Stem Cells; Human Genetics; Developmental Biology;
• 出版者：Higher Education Press
• ISSN：1674-8018
• 卷排序：8

文摘

Non-alcoholic fatty liver disease (NAFLD) is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet (LD), the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treatment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies (GWAS), genomic and proteomic studies. Finally, we discuss a possible mechanism by which the protein 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13) may promote the development of NAFLD.