A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stage merozoites

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• 作者：Gourab Paul ; Arunaditya Deshmukh ; Inderjeet Kaur ; Sumit Rathore…
• 关键词：Plasmodium falciparum ; 6 ; cys proteins ; Glycophorin A ; MSP ; 165
• 刊名：Malaria Journal
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：16
• 期：1
• 全文大小：2335KB
• 刊物主题：Parasitology; Tropical Medicine; Infectious Diseases; Entomology; Microbiology; Public Health;
• 出版者：BioMed Central
• ISSN：1475-2875
• 卷排序：16

文摘

BackgroundThe Plasmodium genome encodes for a number of 6-Cys proteins that contain a module of six cysteine residues forming three intramolecular disulphide bonds. These proteins have been well characterized at transmission as well as hepatic stages of the parasite life cycle. In the present study, a large complex of 6-Cys proteins: Pfs41, Pfs38 and Pfs12 and three other merozoite surface proteins: Glutamate-rich protein (GLURP), SERA5 and MSP-1 were identified on the Plasmodium falciparum merozoite surface.