An expeditious one-pot microwave facilitated versus conventional syntheses: in vivo biological screening and molecular docking studies of some 3,5-disubstituted-4,5-dihydro-(1H)-pyrazole derivatives
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  • 作者：Avinash C. Tripathi ; Savita Upadhyay ; Sarvesh Paliwal…
  • 关键词：2 ; Pyrazolines ; Antidepressant ; Anti ; anxiety ; MAO inhibitors ; Neurotoxicity ; Microwave synthesis ; Molecular docking ; In silico ADME prediction
  • 刊名：Medicinal Chemistry Research
  • 出版年：2016
  • 出版时间：March 2016
  • 年：2016
  • 卷：25
  • 期：3
  • 页码：390-406
  • 全文大小：2,208 KB
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  • 作者单位：Avinash C. Tripathi (1)
    Savita Upadhyay (1)
    Sarvesh Paliwal (2)
    Shailendra K. Saraf (1)

    1. Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Babu Banarasi Das Northern India Institute of Technology, BBD City, Faizabad Road, Chinhat, Lucknow, UP, 226028, India
    2. Department of Pharmacy, Banasthali Vidyapith, Banasthali, Tonk, Rajasthan, 304022, India
  • 刊物主题：Pharmacology/Toxicology; Biochemistry, general; Cell Biology;
  • 出版者：Springer US
  • ISSN：1554-8120
文摘
A series of 3,5-disubstituted-2-pyrazoline derivatives (2a–2t) were synthesized by reacting different aromatic/heteroaromatic aldehydes and ketones, in a two-step reaction through Claisen Schmidt condensation, followed by cyclization of the resulted chalcones with hydrazine hydrate in the presence of a base using conventional and microwave approaches. The synthesized derivatives were characterized by various physicochemical methods, and their chemical structures were established by IR, Mass, 1H-NMR, 13C-NMR spectroscopic data and elemental analysis. The antidepressant with tail suspension test and forced swim test and anti-anxiety with Elevated Plus Maze Test activities were evaluated using suitable animal models. Compounds 2i, and 2j showed noticeable antidepressant activity, by reducing the duration of immobility in both the tests, while compounds 2a and 2b were found to possess good anxiolytic activity, by increasing the number of arm entries and open arm exploratory time at the tested doses (50 and 100 mg/kg b.w.), when compared to the standard drugs imipramine and diazepam, respectively. In order to ascertain the binding interactions of the synthesized derivatives to the MAO-A target protein, molecular docking was employed which demonstrated the key interactions with the amino acid residues Asn181, Phe208, Tyr69, Tyr197, Tyr444 and Met445 at the binding site. In addition, the most active derivatives 2i and 2b showed some imperative conserved interactions of the PDB co-crystal ligand 2Z5X with the amino acid residues at the binding site of MAO-A protein. The results of the study also demonstrated that the Glide gscores of the synthesized derivatives were in close correlation with the in vivo biological activity data, in particular with the forced swim test of the antidepressant activity with a very good correlation coefficient of 0.754103. Furthermore, the ADME properties of the synthesized derivatives were predicted and found to be within the affirmed limits. Keywords 2-Pyrazolines Antidepressant Anti-anxiety MAO inhibitors Neurotoxicity Microwave synthesis Molecular docking In silico ADME prediction
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