Cyclooxygenase in Cancer Prevention and Treatments for Actinic Keratosis

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• 作者：Gareth J. Thomas ; Colin A. Morton
• 关键词：Actinic keratosis ; Cancer prevention ; Cyclooxygenase ; Non ; steroidal anti ; inflammatory drugs ; Prognosis ; Treatment
• 刊名：Dermatology and Therapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：7
• 期：1-supp
• 页码：21-29
• 全文大小：808KB
• 刊物主题：Internal Medicine; Dermatology; Plastic Surgery; Oral and Maxillofacial Surgery; Quality of Life Research;
• 出版者：Springer Healthcare
• ISSN：2190-9172
• 卷排序：7

文摘

Non-steroidal anti-inflammatory drugs (NSAIDs) are a chemically diverse class of drugs that target the cyclooxygenase (COX) pathway and have anti-inflammatory, analgesic, and antipyretic properties. Elevated expression of COX-2 has been associated with tumor progression in skin cancer through multiple mechanisms. We present evidence for a chemoprotective effect of NSAIDs and discuss potential mechanisms of action of COX-2 in cancer. We also discuss the challenges associated with the treatment of actinic keratosis and the factors that should be taken into consideration when selecting a treatment regimen. A range of treatments are reviewed, with an emphasis on combination therapies.