EGR1 controls divergent cellular responses of distinctive nucleus pulposus cell types

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• 作者：Guus G. H. van den Akker ; Don A. M. Surtel ; Andy Cremers…
• 关键词：Intervertebral disc ; Nucleus pulposus ; Cell line ; EGR1 ; Specific cell responses ; IL ; 1β ; Inflammation ; Differentiation
• 刊名：BMC Musculoskeletal Disorders
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：2,099 KB
• 刊物主题：Orthopedics; Rehabilitation; Rheumatology; Sports Medicine; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2474

文摘

Background Immediate early genes (IEGs) encode transcription factors which serve as first line response modules to altered conditions and mediate appropriate cell responses. The immediate early response gene EGR1 is involved in physiological adaptation of numerous different cell types. We have previously shown a role for EGR1 in controlling processes supporting chondrogenic differentiation. We recently established a unique set of phenotypically distinct cell lines from the human nucleus pulposus (NP). Extensive characterization showed that these NP cellular subtypes represented progenitor-like cell types and more functionally mature cells.