Insulin resistance is associated with poorer verbal fluency performance in women

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• 作者：Laura L. Ekblad ; Juha O. Rinne ; Pauli J. Puukka ; Hanna K. Laine…
• 关键词：Alzheimer鈥檚 disease ; APOE*E4 genotype ; Categorical verbal fluency ; Cognition ; HOMA ; IR ; Insulin resistance ; Sex difference
• 刊名：Diabetologia
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：58
• 期：11
• 页码：2545-2553
• 全文大小：380 KB
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• 作者单位：Laura L. Ekblad (1) (2)
  Juha O. Rinne (1) (3)
  Pauli J. Puukka (4)
  Hanna K. Laine (5) (6)
  Satu E. Ahtiluoto (7)
  Raimo O. Sulkava (7)
  Matti H. Viitanen (5) (8)
  Antti M. Jula (4)
  
  1. Turku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, 20521, Turku, Finland
  2. Turku Health Care Centre, Turku, Finland
  3. Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland
  4. National Institute for Health and Welfare (THL), Turku, Finland
  5. Turku City Hospital, University of Turku, Turku, Finland
  6. Department of Medicine, University of Turku, Turku, Finland
  7. University of Eastern Finland, Kuopio, Finland
  8. Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Type 2 diabetes is an independent risk factor for cognitive decline. Insulin resistance occurring during midlife may increase the risk of cognitive decline later in life. We hypothesised that insulin resistance is associated with poorer cognitive performance and that sex and APOE*E4 might modulate this association.