Suppression of neuronal excitability by the secretion of the lamprey (Lampetra japonica) provides a mechanism for its evolutionary stability

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• 作者：Shaopeng Chi (1)
  Rong Xiao (1) (3)
  Qingwei Li (2)
  Liwei Zhou (2)
  Rongqiao He (1)
  Zhi Qi (1)
  
• 关键词：Lamprey ; Lampetra japonica ; Action potential ; Sodium channel ; CRISP ; Nociceptive response
• 刊名：Pfl眉gers Archiv - European Journal of Physiology
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：458
• 期：3
• 页码：537-545
• 全文大小：501KB
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• 作者单位：Shaopeng Chi (1)
  Rong Xiao (1) (3)
  Qingwei Li (2)
  Liwei Zhou (2)
  Rongqiao He (1)
  Zhi Qi (1)
  
  1. State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, 15 Datun Rd, Beijing, 100101, China
  3. Graduate University of Chinese Academy of Sciences, 19A Yuquan Rd, Beijing, 100039, China
  2. School of Life Sciences, Liaoning Normal University, Dalian, 116029, China
  
• ISSN：1432-2013

文摘

Lampreys are one of the most primitive vertebrates still living today. They attach themselves to the body surface of the host fish through their sucker-like mouths and suck blood of the host for days. Recent fossil evidence has indicated that morphology of lampreys in the late Devonian period, over 360 million years ago, already possessed the present day major characteristics, suggesting the evolutionary stability of a highly specialized parasitic feeding habit. Obviously, nociceptive responses and hemostasis of the host are two major barriers to long-term feeding of the parasitic lamprey. It has been found, to counteract hemostasis of the host, that paired buccal glands of lampreys secrete antihemostatic compounds to prevent blood of the host from coagulation. However, it is not known how lampreys make the host lose nociceptive responses. Here, we prepared components of the crude extract from the buccal glands of the lampreys (Lampetra japonica). Then, we show that crude extract and one of its purified components reduce the firing frequency of neuronal action potentials probably through inhibiting the voltage-dependent Na+ channels. As the voltage-gated Na+ channels are highly conserved throughout evolution, we argue that the secretion of the lampreys could exert the similar effect on the Na+ channels of their host fish as well. Therefore, together with its antihemostatic effect, the secretion due to its inhibitory effect on neuronal excitability might provide a mechanism for the parasitic lampreys to keep their evolutionary stability.