Recurrence patterns of glioblastoma treated with postoperative radiation therapy: relationship between extent of resection and progression-free interval

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• 作者：Ryuji Murakami (1)
  Toshinori Hirai (2)
  Hideo Nakamura (3)
  Mitsuhiro Furusawa (4)
  Yuji Nakaguchi (1)
  Hiroyuki Uetani (2)
  Mika Kitajima (2)
  Yasuyuki Yamashita (2)
  
• 关键词：Glioblastoma ; Magnetic resonance imaging ; Postoperative radiation therapy ; Extent of resection ; Progression ; free survival
• 刊名：Japanese Journal of Radiology
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：30
• 期：3
• 页码：193-197
• 全文大小：286KB
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• 作者单位：Ryuji Murakami (1)
  Toshinori Hirai (2)
  Hideo Nakamura (3)
  Mitsuhiro Furusawa (4)
  Yuji Nakaguchi (1)
  Hiroyuki Uetani (2)
  Mika Kitajima (2)
  Yasuyuki Yamashita (2)
  
  1. Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, 4-24-1 Kuhonji, Kumamoto, 862-0976, Japan
  2. Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
  3. Department of Neurosurgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
  4. Department of Radiology, Kumamoto City Hospital, Kumamoto, Japan
  

文摘

Purpose To evaluate progression pattern and progression-free interval for patients with glioblastoma multiforme (GBM), on the basis of the extent of resection. Materials and methods Between January 2000 and September 2009, 138 patients with GBM underwent postoperative radiation therapy and longitudinal magnetic resonance imaging studies. The operations were classified as biopsy, partial resection (PR), and gross total resection (GTR). Progression patterns were classified as gross tumor volume (GTV), T2 hyperintensity (T2h), distant, and free. We used the Kruskal–Wallis test to compare progression-free intervals on the basis of the extent of resection and the progression pattern. Results Recurrence of biopsied and PR tumors at the GTV site was 100 and 97%, respectively. The median progression-free interval was 3?months for biopsied (n?=?29), 4?months for PR (n?=?70), and 8?months for GTR (n?=?39) tumors (p?<?0.05). The median progression-free interval for progression patterns classified as GTV (n?=?97), T2h (n?=?24), distant (n?=?12), and free (n?=?5) was 3 (p?<?0.05), 7, 8, and 29?months, respectively. Conclusion Control of the GTV can increase the progression-free interval because gross residual tumors progress earlier than infiltrating tumor cells do.