Increased serum gamma-glutamyltransferase levels are associated with ventricular instability in type 2 diabetes

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• 作者：Kun Wang ; Ling Li ; Yang Wu ; Yu Yang ; Jie Chen ; Danyu Zhang ; Zhoujun Liu…
• 关键词：Type 2 diabetes mellitus (T2DM) ; Gamma ; glutamyltransferase (GGT) ; Corrected QT interval (QTc) ; QT dispersion (QTd) ; Ventricular instability
• 刊名：Endocrine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：52
• 期：1
• 页码：63-72
• 全文大小：540 KB
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• 作者单位：Kun Wang (1)
  Ling Li (2)
  Yang Wu (3)
  Yu Yang (1)
  Jie Chen (1)
  Danyu Zhang (1)
  Zhoujun Liu (1)
  Juan Xu (1)
  Meng Cao (1)
  Xiaodong Mao (1)
  Chao Liu (1)
  
  1. Department of Endocrinology, Affiliated Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, 100, Hongshan Road, Nanjing, 210028, China
  2. Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, 87, Dingjiaqiao Road, Nanjing, 210009, China
  3. Department of Endocrinology, The First People’s Hospital of Changzhou, Third Affiliated Hospital of Suzhou University, 185, Juqian Road, Changzhou, 213003, China
  
• 刊物主题：Endocrinology; Diabetes; Internal Medicine; Science, general;
• 出版者：Springer US
• ISSN：1559-0100

文摘

The purpose of our study is to examine the association between serum GGT levels and ventricular instability in Chinese patients with T2DM. We conducted a cross-sectional, community-based study in Nanjing, China from June to November 2011. Among 10,050 patients aged 40–79 years, we enrolled 2444 with pre-diabetes, 2496 with T2DM, and 4521 without diabetes (non-diabetes). Electrocardiograms were performed to measure the QT interval corrected for heart rate (QTc) and QT interval dispersion (QTd). Serum GGT levels, metabolic parameters, body mass index, and blood pressure were also measured. We found that there were no significant associations of increased QTc/QTd with serum GGT levels in participants with pre-existing T2DM and non-diabetes, after adjusting for age, duration of diabetes, and metabolic parameters. Even after adjustment, higher risks of QTc ≥ 440 ms/√s and QTd ≥ 58 ms were found in participants with serum GGT levels ≥49 U/L compared with those with <15 U/L in the pre-diabetes (QTc: OR 1.96, 95 % CI 1.23–2.47; QTd: OR 1.34, 95 % CI 1.07–1.94) and newly diagnosed T2DM (QTc: OR 2.01, 95 % CI 1.39–2.51; QTd: OR 1.53, 95 % CI 1.03–1.99) groups. We conclude that Increased serum GGT levels are associated with some markers of ventricular repolarization abnormalities in the early stage of T2DM.