An expression analysis of markers of radiation-induced skin fibrosis and angiogenesis in wound healing disorders of the head and neck

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• 作者：Steffen Koerdt ; Nils H. Rohleder ; Niklas Rommel ; Christopher Nobis…
• 关键词：Head and neck cancer ; Radiation ; Neck dissection ; von –Willebrand factor ; Procollagen ; alpha ; Tumor–growth factor ; beta ; Wound healing disorder
• 刊名：Radiation Oncology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：10
• 期：1
• 全文大小：2,226 KB
• 刊物主题：Oncology; Radiotherapy;
• 出版者：BioMed Central
• ISSN：1748-717X

文摘

Background Radiation-induced fibrosis (RIF) is one of the severe long-term side effects of radiation therapy (RT) with a crucial impact on the development of postoperative wound healing disorders (WHD). The grades of fibrosis vary between mild to severe depending on individual radiosensitivity. In this study, we have investigated the molecular pathways that influence RIF and have correlated data from immunohistochemistry (IHC) for von –Willebrand Factor (vWF) and from Real-Time Polymerase Chain Reaction (RT-PCR) concerning markers such as Transforming Growth Factor (TGF)-β ₁, and vWF, with clinical data concerning the occurrence of WHD during follow-up.