Deletion in chromosome 11 and Bcl-1/Cyclin D1 alterations are independently associated with the development of uterine cervical carcinoma

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• 作者：Ratnesh Kumar Singh ; Santanu Dasgupta ; Nilanjana Bhattacharya ; Neelanjana Chunder ; Ranjit Mondal ; Anup Roy ; Syamsundar Mandal ; Susanta Roychowdhury and Chinmay Kumar Panda
• 关键词：Uterine cervical carcinoma ; HPV infection ; Chromosome 11 ; LOH ; Tumor suppressor gene (s) ; Bcl ; 1/Cyclin D1 alteration
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2005
• 出版时间：June 2005
• 年：2005
• 卷：131
• 期：6
• 页码：395-406
• 全文大小：814 KB

文摘

Purpose The aim of this study was to understand whether there is any association between specific deleted regions in chromosome 11 (chr.11) and alteration (amplification/rearrangement) of Bcl-1/Cyclin D1 locus, located at 11q13, in uterine cervical carcinoma (CA-CX).