Insulin induces Ca2+ oscillations in white fat adipocytes via PI3K and PLC

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• 作者：E. A. Turovsky ; M. V. Turovskaya…
• 关键词：insulin ; [Ca2+]i oscillations ; phosphoinositide 3 ; kinase (PI3K) ; protein kinase B (Akt/PKB) ; endothelial NO synthase (eNOS) ; inositol 3 ; phosphate receptor (IP3R)
• 刊名：Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：10
• 期：1
• 页码：53-59
• 全文大小：602 KB
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• 作者单位：E. A. Turovsky (1)
  M. V. Turovskaya (1)
  V. P. Zinchenko (1) (2)
  V. V. Dynnik (1) (3)
  L. P. Dolgacheva (1) (2)
  
  1. Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia
  2. Pushchino State Institute of Natural Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia
  3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia
  
• 刊物主题：Cell Biology;
• 出版者：Springer US
• ISSN：1990-7494

文摘

Adipocytes of white adipose tissue are the cells maintaining glucose homeostasis in an organism, which is controlled by insulin. Insulin stimulates the translocation of glucose transporter GLUT4 from the cytosol into the cell membrane, as well as glucose transport and utilization in these cells. Here we show that insulin-induced [Ca2+]_i oscillations are supported by the two signaling pathways involving: (1) phosphoinositide 3-kinase (PI3K), protein kinase B (Akt/PKB), endothelial NO synthase (eNOS), nitric oxide (NO), and ryanodine receptor (RyR) and (2) phospholipase C (PLC) and inositol 3-phosphate receptor (IP₃R). Thus, the PI3K Akt/PKB signaling pathway initiates not only metabolic but also Ca2+-signaling pathways in response to insulin.