S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression

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S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression

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作者：Gumeng Cheng ; Kailin Tian ; Lu Zhang…
关键词：Retinal neovascularization ; Oxygen ; induced retinopathy ; Adenovirus ; mediated RNAi transfer ; S100A4 ; cAMP response element ; binding protein
刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
出版年：2016
出版时间：January 2016
年：2016
卷：254
期：1
页码：97-108
全文大小：9,339 KB
参考文献：1.Lee P, Wang CC, Adamis AP (1998) Ocular neovascularization: an epidemiologic review. Surv Ophthalmol 43(3):245–269PubMed CrossRef
2.Hardy P, Dumont I, Bhattacharya M, Hou X, Lachapelle P, Varma DR, Chemtob S (2000) Oxidants, nitric oxide and prostanoids in the developing ocular vasculature: a basis for ischemic retinopathy. Cardiovasc Res 47(3):489–509PubMed CrossRef
3.Campochiaro PA (2000) Retinal and choroidal neovascularization. J Cell Physiol 184(3):301–310. doi:10.1002/1097-4652(200009)184:3<301::AID-JCP3>3.0.CO;2-H PubMed CrossRef
4.Bussolino F, Mantovani A, Persico G (1997) Molecular mechanisms of blood vessel formation. Trends Biochem Sci 22(7):251–256PubMed CrossRef
5.Miller JW, Adamis AP, Aiello LP (1997) Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. Diabetes Metab Rev 13(1):37–50PubMed CrossRef
6.Ali Rahman IS, Li CR, Lai CM, Rakoczy EP (2011) In vivo monitoring of VEGF-induced retinal damage in the Kimba mouse model of retinal neovascularization. Curr Eye Res 36(7):654–662. doi:10.3109/02713683.2010.551172 PubMed CrossRef
7.Chen P, Yin H, Wang Y, Wang Y, Xie L (2012) Inhibition of VEGF expression and corneal neovascularization by shRNA targeting HIF-1alpha in a mouse model of closed eye contact lens wear. Mol Vis 18:864–873PubMed PubMedCentral
8.Hewing NJ, Weskamp G, Vermaat J, Farage E, Glomski K, Swendeman S, Chan RV, Chiang MF, Khokha R, Anand-Apte B, Blobel CP (2013) Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci 54(1):864–870. doi:10.1167/iovs.12-10954 PubMed PubMedCentral CrossRef
9.Lofqvist C, Willett KL, Aspegren O, Smith AC, Aderman CM, Connor KM, Chen J, Hellstrom A, Smith LE (2009) Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci 50(4):1831–1837. doi:10.1167/iovs.08-2903 PubMed CrossRef
10.Vanhaesebrouck S, Daniels H, Moons L, Vanhole C, Carmeliet P, De Zegher F (2009) Oxygen-induced retinopathy in mice: amplification by neonatal IGF-I deficit and attenuation by IGF-I administration. Pediatr Res 65(3):307–310. doi:10.1203/PDR.0b013e3181973dc8 PubMed CrossRef
11.Lin M, Chen Y, Jin J, Hu Y, Zhou KK, Zhu M, Le YZ, Ge J, Johnson RS, Ma JX (2011) Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal muller cells. Diabetologia 54(6):1554–1566. doi:10.1007/s00125-011-2081-0 PubMed CrossRef
12.Xia XB, Xiong SQ, Xu HZ, Jiang J, Li Y (2008) Suppression of retinal neovascularization by shRNA targeting HIF-1alpha. Curr Eye Res 33(10):892–902. doi:10.1080/02713680802416670 PubMed CrossRef
13.Boye K, Maelandsmo GM (2010) S100A4 and metastasis: a small actor playing many roles. Am J Pathol 176(2):528–535. doi:10.2353/ajpath.2010.090526 PubMed PubMedCentral CrossRef
14.Saleem M, Kweon MH, Johnson JJ, Adhami VM, Elcheva I, Khan N, Bin Hafeez B, Bhat KM, Sarfaraz S, Reagan-Shaw S, Spiegelman VS, Setaluri V, Mukhtar H (2006) S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9. Proc Natl Acad Sci U S A 103(40):14825–14830. doi:10.1073/pnas.0606747103 PubMed PubMedCentral CrossRef
15.Zhang J, Zhang DL, Jiao XL, Dong Q (2013) S100A4 regulates migration and invasion in hepatocellular carcinoma HepG2 cells via NF-kappaB-dependent MMP-9 signal. Eur Rev Med Pharmacol Sci 17(17):2372–2382PubMed
16.Tamaki Y, Iwanaga Y, Niizuma S, Kawashima T, Kato T, Inuzuka Y, Horie T, Morooka H, Takase T, Akahashi Y, Kobuke K, Ono K, Shioi T, Sheikh SP, Ambartsumian N, Lukanidin E, Koshimizu TA, Miyazaki S, Kimura T (2013) Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts. J Mol Cell Cardiol 57:72–81. doi:10.1016/j.yjmcc.2013.01.007 PubMed CrossRef
17.He J, Xu Y, Koya D, Kanasaki K (2013) Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease. Clin Exp Nephrol 17(4):488–497. doi:10.1007/s10157-013-0781-0 PubMed CrossRef
18.Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R (2008) Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol: JASN 19(12):2282–2287. doi:10.1681/ASN.2008050513 PubMed PubMedCentral CrossRef
19.Tang RN, Lv LL, Zhang JD, Dai HY, Li Q, Zheng M, Ni J, Ma KL, Liu BC (2013) Effects of angiotensin II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic rats. Int J Cardiol 162(2):92–99. doi:10.1016/j.ijcard.2011.06.052 PubMed CrossRef
20.Widyantoro B, Emoto N, Nakayama K, Anggrahini DW, Adiarto S, Iwasa N, Yagi K, Miyagawa K, Rikitake Y, Suzuki T, Kisanuki YY, Yanagisawa M, Hirata K (2010) Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition. Circulation 121(22):2407–2418. doi:10.1161/CIRCULATIONAHA.110.938217 PubMed CrossRef
21.Abu El-Asrar AM, Nawaz MI, De Hertogh G, Alam K, Siddiquei MM, Van den Eynde K, Mousa A, Mohammad G, Geboes K, Opdenakker G (2014) S100A4 is upregulated in proliferative diabetic retinopathy and correlates with markers of angiogenesis and fibrogenesis. Mol Vis 20:1209–1224PubMed PubMedCentral
22.Zhang ZJ (2014) Artificial trans-acting small interfering RNA: a tool for plant biology study and crop improvements. Planta 239(6):1139–1146. doi:10.1007/s00425-014-2054-x PubMed CrossRef
23.Connor KM, Krah NM, Dennison RJ, Aderman CM, Chen J, Guerin KI, Sapieha P, Stahl A, Willett KL, Smith LE (2009) Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc 4(11):1565–1573. doi:10.1038/nprot.2009.187 PubMed PubMedCentral CrossRef
24.Zhong X, Huang H, Shen J, Zacchigna S, Zentilin L, Giacca M, Vinores SA (2011) Vascular endothelial growth factor-B gene transfer exacerbates retinal and choroidal neovascularization and vasopermeability without promoting inflammation. Mol Vis 17:492–507PubMed PubMedCentral
25.Chiu K, Chang RC, So KF (2007) Intravitreous injection for establishing ocular diseases model. J Vis Exp: JoVE 8:313. doi:10.3791/313 PubMed
26.Fan W, Xing Y, Zhong Y, Chen C, Shen Y (2013) Expression of NMDA receptor subunit 1 in the rat retina. Acta Histochem 115(1):42–47. doi:10.1016/j.acthis.2012.03.005 PubMed CrossRef
27.Smith LE, Wesolowski E, McLellan A, Kostyk SK, D’Amato R, Sullivan R, D’Amore PA (1994) Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 35(1):101–111PubMed
28.Chen YY, Liu SL, Hu DP, Xing YQ, Shen Y (2014) N -methyl- N -nitrosourea-induced retinal degeneration in mice. Exp Eye Res 121:102–113. doi:10.1016/j.exer.2013.12.019 PubMed CrossRef
29.Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods (San Diego, Calif) 25(4):402–408. doi:10.1006/meth.2001.1262 CrossRef
30.Buch H, Vinding T, Nielsen NV (2001) Prevalence and causes of visual impairment according to World Health Organization and United States criteria in an aged, urban Scandinavian population: the Copenhagen City Eye Study. Ophthalmology 108(12):2347–2357PubMed CrossRef
31.Congdon N, O’Colmain B, Klaver CC, Klein R, Munoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P, Eye Diseases Prevalence Research G (2004) Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 122(4):477–485. doi:10.1001/archopht.122.4.477 PubMed CrossRef
32.Hernandez C, Simo R (2007) Strategies for blocking angiogenesis in diabetic retinopathy: from basic science to clinical practice. Exp Opin Investig Drugs 16(8):1209–1226. doi:10.1517/13543784.16.8.1209 CrossRef
33.Nicholson BP, Schachat AP (2010) A review of clinical trials of anti-VEGF agents for diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Klin Exp Ophthalmol 248(7):915–930. doi:10.1007/s00417-010-1315-z CrossRef
34.Kim J, Kim CS, Lee YM, Jo K, Shin SD, Kim JS (2012) Methylglyoxal induces hyperpermeability of the blood-retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Klin Exp Ophthalmol 250(5):691–697. doi:10.1007/s00417-011-1912-5 CrossRef
35.Peng S, Gan G, Rao VS, Adelman RA, Rizzolo LJ (2012) Effects of proinflammatory cytokines on the claudin-19 rich tight junctions of human retinal pigment epithelium. Invest Ophthalmol Vis Sci 53(8):5016–5028. doi:10.1167/iovs.11-8311 PubMed PubMedCentral CrossRef
36.Ochiya T, Takenaga K, Endo H (2014) Silencing of S100A4, a metastasis-associated protein, in endothelial cells inhibits tumor angiogenesis and growth. Angiogenesis 17(1):17–26. doi:10.1007/s10456-013-9372-7 PubMed PubMedCentral CrossRef
37.Yonemura Y, Endou Y, Kimura K, Fushida S, Bandou E, Taniguchi K, Kinoshita K, Ninomiya I, Sugiyama K, Heizmann CW, Schafer BW, Sasaki T (2000) Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer. Clin Cancer Res Off J Am Assoc Cancer Res 6(11):4234–4242
38.Takenaga K, Nakanishi H, Wada K, Suzuki M, Matsuzaki O, Matsuura A, Endo H (1997) Increased expression of S100A4, a metastasis-associated gene, in human colorectal adenocarcinomas. Clin Cancer Res Off J Am Assoc Cancer Res 3(12 Pt 1):2309–2316
39.Rudland PS, Platt-Higgins A, Renshaw C, West CR, Winstanley JH, Robertson L, Barraclough R (2000) Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer. Cancer Res 60(6):1595–1603PubMed
40.Rosty C, Ueki T, Argani P, Jansen M, Yeo CJ, Cameron JL, Hruban RH, Goggins M (2002) Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol 160(1):45–50. doi:10.1016/S0002-9440(10)64347-7 PubMed PubMedCentral CrossRef
41.Platt-Higgins AM, Renshaw CA, West CR, Winstanley JH, De Silva Rudland S, Barraclough R, Rudland PS (2000) Comparison of the metastasis-inducing protein S100A4 (p9ka) with other prognostic markers in human breast cancer. Int J Cancer J Int Du Cancer 89(2):198–208CrossRef
42.Li C, Zhang F, Wang Y (2010) S100A proteins in the pathogenesis of experimental corneal neovascularization. Mol Vis 16:2225–2235
43.Mayr B, Montminy M (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2(8):599–609. doi:10.1038/35085068 PubMed CrossRef
44.Peshavariya HM, Liu GS, Chang CW, Jiang F, Chan EC, Dusting GJ (2014) Prostacyclin signaling boosts NADPH oxidase 4 in the endothelium promoting cytoprotection and angiogenesis. Antioxid Redox Signal 20(17):2710–2725. doi:10.1089/ars.2013.5374 PubMed CrossRef
45.Darashchonak N, Koepsell B, Bogdanova N, von Versen-Hoynck F (2014) Adenosine A2B receptors induce proliferation, invasion and activation of cAMP response element binding protein (CREB) in trophoblast cells. BMC Pregnancy Childbirth 14:2. doi:10.1186/1471-2393-14-2 PubMed PubMedCentral CrossRef
46.Barresi V, Branca G, Caffo M, Tuccari G (2015) p-CREB expression in human meningiomas: correlation with angiogenesis and recurrence risk. J Neuro-Oncol 122(1):87–95. doi:10.1007/s11060-014-1706-9 CrossRef
47.Meller R, Minami M, Cameron JA, Impey S, Chen D, Lan JQ, Henshall DC, Simon RP (2005) CREB-mediated Bcl-2 protein expression after ischemic preconditioning. J Cereb Blood Flow Metab 25(2):234–246. doi:10.1038/sj.jcbfm.9600024 PubMed CrossRef
48.Wang S, Sorenson CM, Sheibani N (2005) Attenuation of retinal vascular development and neovascularization during oxygen-induced ischemic retinopathy in Bcl-2−/− mice. Dev Biol 279(1):205–219. doi:10.1016/j.ydbio.2004.12.017 PubMed CrossRef
49.Hui K, Yang Y, Shi K, Luo H, Duan J, An J, Wu P, Ci Y, Shi L, Xu C (2014) The p38 MAPK-regulated PKD1/CREB/Bcl-2 pathway contributes to selenite-induced colorectal cancer cell apoptosis in vitro and in vivo. Cancer Lett 354(1):189–199. doi:10.1016/j.canlet.2014.08.009 PubMed CrossRef
50.Fujii M, Sherchan P, Soejima Y, Hasegawa Y, Flores J, Doycheva D, Zhang JH (2014) Cannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB-Bcl-2 pathway after subarachnoid hemorrhage in rats. Exp Neurol 261:396–403. doi:10.1016/j.expneurol.2014.07.005 PubMed CrossRef
51.Shankar E, Krishnamurthy S, Paranandi R, Basu A (2010) PKCepsilon induces Bcl-2 by activating CREB. Int J Oncol 36(4):883–888PubMed
52.Boland K, Flanagan L, Prehn JH (2013) Paracrine control of tissue regeneration and cell proliferation by Caspase-3. Cell Death Dis 4:e725. doi:10.1038/cddis.2013.250 PubMed PubMedCentral CrossRef
53.Nassar A, Lawson D, Cotsonis G, Cohen C (2008) Survivin and caspase-3 expression in breast cancer: correlation with prognostic parameters, proliferation, angiogenesis, and outcome. Appl Immunohistochem Molecular Morphol: AIMM/Off Publ Soc Appl Immunohistochem 16(2):113–120. doi:10.1097/PAI.0b013e318032ea73 CrossRef
54.Volm M, Mattern J, Koomagi R (1999) Inverse correlation between apoptotic (Fas ligand, caspase-3) and angiogenic factors (VEGF, microvessel density) in squamous cell lung carcinomas. Anticancer Res 19(3A):1669–1671PubMed
55.Wang H, Chen X (2013) Effects of a Rho kinase inhibitor on the sequential expression of ICAM-1, HIF-1alpha, Bcl-2 and caspase-3 in the retina of rats with oxygen-induced retinopathy. Int J Mol Med 32(2):457–463. doi:10.3892/ijmm.2013.1410 PubMed
作者单位：Gumeng Cheng (1)
Kailin Tian (1)
Lu Zhang (1)
Ning Yang (1)
Yiqiao Xing (1)
Tao He (1)

1. Eye Center, Renmin Hospital of Wuhan University, 238 Jiefang Rd., Wuhan, Hubei Province, 430060, China
刊物类别：Medicine
刊物主题：Medicine & Public Health
Ophthalmology
出版者：Springer Berlin / Heidelberg
ISSN：1435-702X

文摘

Purpose To investigate the possible role of S100A4 in retinal neovascularization (RNV), as well as the underlying mechanism, in a mouse model of oxygen-induced retinopathy (OIR).