Prognostic significance of S100A4-expression and subcellular localization in early-stage breast cancer

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• 作者：Eivind Valen Egeland ; Kjetil Boye ; Daehoon Park…
• 关键词：Breast cancer ; S100A4 ; Nuclear localization ; Prognostic marker
• 刊名：Breast Cancer Research and Treatment
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：162
• 期：1
• 页码：127-137
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Oncology;
• 出版者：Springer US
• ISSN：1573-7217
• 卷排序：162

文摘

PurposePrognostic factors are useful in order to identify early-stage breast cancer patients who might benefit from adjuvant treatment. The metastasis-promoting protein S100A4 has previously been associated with poor prognosis in breast cancer patients. The protein is expressed in diverse subcellular compartments, including the cytoplasm, extracellular space, and nucleus. Nuclear expression is an independent predictor of poor outcome in several cancer types, but the significance of subcellular expression has not yet been assessed in breast cancer.