Differences in UGT1A1, UGT1A7, and UGT1A9 Polymorphisms between Uzbek and Japanese Populations

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• 作者：Hiromichi Maeda (1)
  Shoichi Hazama (2)
  Abdiev Shavkat (3)
  Ken Okamoto (1)
  Koji Oba (4)
  Junichi Sakamoto (5)
  Kenichi Takahashi (6)
  Masaki Oka (2)
  Daisuke Nakamura (7)
  Ryouichi Tsunedomi (2)
  Naoko Okayama (8)
  Hideyuki Mishima (9)
  Michiya Kobayashi (1)
  
• 刊名：Molecular Diagnosis & Therapy
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：18
• 期：3
• 页码：333-342
• 全文大小：
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• 作者单位：Hiromichi Maeda (1)
  Shoichi Hazama (2)
  Abdiev Shavkat (3)
  Ken Okamoto (1)
  Koji Oba (4)
  Junichi Sakamoto (5)
  Kenichi Takahashi (6)
  Masaki Oka (2)
  Daisuke Nakamura (7)
  Ryouichi Tsunedomi (2)
  Naoko Okayama (8)
  Hideyuki Mishima (9)
  Michiya Kobayashi (1)
  
  1. Department of Human Health and Medical Sciences, Kochi Medical School, Kohasu, Oko-cho, Nankoku, 783-8505, Japan
  2. Department of Digestive Surgery and Surgical Oncology (Surgery II), Yamaguchi University Graduate School of Medicine, Ube, 755-8505, Japan
  3. Nozaki Tokushukai Hospital, Daito, 574-0074, Japan
  4. Translational Research and Clinical Trial Center, Hokkaido University Hospital, Sapporo, 060-8638, Japan
  5. Tokai Central Hospital, Kakamigahara, 504-8601, Japan
  6. Department of Surgery, Aomori Prefectural Central Hospital, Aomori, 030-8553, Japan
  7. Chikamori Hospital, Kochi, 780-8522, Japan
  8. Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube, 755-8505, Japan
  9. Department of Surgery, Osaka National Hospital, Osaka, 565-0871, Japan
  
• ISSN：1179-2000

文摘

Background and Objectives Uridine-diphosphate glucuronosyltransferase 1A (UGT1A) is a key enzyme involved in irinotecan metabolism, and polymorphisms in the UGT1A gene are associated with irinotecan-induced toxicity. The aim of this study was to elucidate the allele frequencies of UGT1A polymorphisms in healthy Uzbek volunteers, and to compare them with those of the Japanese population. Method A total of 97 healthy volunteers from Uzbekistan were enrolled and blood samples were collected from each participant. Genotyping analysis was performed by fragment size analysis for UGT1A1*28, direct sequencing for UGT1A7*3 and UGT1A9*22, and TaqMan assays for UGT1A1*93, UGT1A1*6, UGT1A1*27, UGT1A1*60, and UGT1A7*12. The frequencies of polymorphisms were compared with the Japanese population by using the data previously reported from our study group. Results When the Uzbek and Japanese populations were compared, heterozygotes or homozygotes for UGT1A1*28, UGT1A1*60, and UGT1A1*93 were significantly more frequent in the Uzbek population (P?<?0.01). The rate of UGT1A7*12 was not significantly different between the two populations, whereas UGT1A1*6 and UGT1A9*22 were significantly less frequent in the Uzbek population (P?<?0.05). UGT1A7*1 were less prevalent in the Uzbek population than in the Japanese population (P?<?0.01). Conclusion The Uzbek population has different frequencies of polymorphisms in UGT1A genes compared with the Japanese population. A comprehensive study of the influence of UGT1A1 polymorphisms on the risk of irinotecan-induced toxicity is necessary for optimal use of irinotecan treatment.